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• W2012189675 endingPage "14" @default.
• W2012189675 startingPage "3" @default.
• W2012189675 abstract "Non-alcoholic fatty liver disease (NAFLD) is an umbrella term, which encompasses simple steatosis and non-alcoholic steatohepatitis (NASH). The entire spectrum of NAFLD has been associated with metabolic syndrome. NASH is associated with increased mortality compared with that of the general population. Many therapeutic options for NASH have been studied. However, there is very little evidence supporting the efficacy of most regimens for the treatment of NASH.To provide a review focusing on the current therapeutic options available for patients with NASH as well as to briefly introduce possible future interventions.A MEDLINE, Pubmed and Cochrane Review database search using a combination of keywords, which included non-alcoholic fatty liver disease, non-alcoholic hepatic steatosis, NAFLD, NASH, treatment, therapeutics, vitamin E, orlistat and bariatric surgery. An overall summary of the articles was developed for each section of discussion in this review.NASH associated with metabolic syndrome can progress advanced fibrosis and cirrhosis. Weight loss and lifestyle modification have been shown to improve NASH. Other medications used for weight loss and metabolic syndrome have been evaluated, such as orlistat, metformin and thiazolidinediones. Alternative regimens using ursodeoxycholic acid, statins and probiotics as well as bariatric surgery have been evaluated, but have not been recommended as first-line treatment for NASH. Vitamin E for NASH patients without diabetes seems to be promising. The lack of effective treatment for NASH suggests the heterogeneity of patients presenting with the NASH phenotype. The best treatment strategy for these patients may be to identify their pathogenic target and develop personalised treatment protocols.Currently, there are few options available for the management of NASH. Future targeted treatment strategies based on the pathogenic pathways may be needed to develop effective treatment for patients with NASH." @default.
• W2012189675 created "2016-06-24" @default.
• W2012189675 creator A5003330826 @default.
• W2012189675 creator A5065813253 @default.
• W2012189675 creator A5071030296 @default.
• W2012189675 creator A5071309777 @default.
• W2012189675 creator A5080386622 @default.
• W2012189675 date "2013-11-10" @default.
• W2012189675 modified "2023-10-03" @default.
• W2012189675 title "Systematic review with meta-analysis: non-alcoholic steatohepatitis - a case for personalised treatment based on pathogenic targets" @default.
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• W2012189675 doi "https://doi.org/10.1111/apt.12543" @default.

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