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• W2012190231 endingPage "e1000668" @default.
• W2012190231 startingPage "e1000668" @default.
• W2012190231 abstract "The important human pathogen Pseudomonas aeruginosa has been linked to numerous biofilm-related chronic infections. Here, we demonstrate that biofilm formation following the transition to the surface attached lifestyle is regulated by three previously undescribed two-component systems: BfiSR (PA4196-4197) harboring an RpoD-like domain, an OmpR-like BfmSR (PA4101-4102), and MifSR (PA5511-5512) belonging to the family of NtrC-like transcriptional regulators. These two-component systems become sequentially phosphorylated during biofilm formation. Inactivation of bfiS, bfmR, and mifR arrested biofilm formation at the transition to the irreversible attachment, maturation-1 and -2 stages, respectively, as indicated by analyses of biofilm architecture, and protein and phosphoprotein patterns. Moreover, discontinuation of bfiS, bfmR, and mifR expression in established biofilms resulted in the collapse of biofilms to an earlier developmental stage, indicating a requirement for these regulatory systems for the development and maintenance of normal biofilm architecture. Interestingly, inactivation did not affect planktonic growth, motility, polysaccharide production, or initial attachment. Further, we demonstrate the interdependency of this two-component systems network with GacS (PA0928), which was found to play a dual role in biofilm formation. This work describes a novel signal transduction network regulating committed biofilm developmental steps following attachment, in which phosphorelays and two sigma factor-dependent response regulators appear to be key components of the regulatory machinery that coordinates gene expression during P. aeruginosa biofilm development in response to environmental cues." @default.
• W2012190231 created "2016-06-24" @default.
• W2012190231 creator A5038510134 @default.
• W2012190231 creator A5058972119 @default.
• W2012190231 date "2009-11-20" @default.
• W2012190231 modified "2023-10-18" @default.
• W2012190231 title "A Novel Signaling Network Essential for Regulating Pseudomonas aeruginosa Biofilm Development" @default.
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• W2012190231 doi "https://doi.org/10.1371/journal.ppat.1000668" @default.
• W2012190231 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2774163" @default.
• W2012190231 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19936057" @default.
• W2012190231 hasPublicationYear "2009" @default.
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