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• W2012190775 abstract "In previous work the metal-polypeptide co-ordinative bonds in the major protein species of a reconstituted [ 113 Cd 7 ]metallothionein-2 preparation from rabbit liver in aqueous solution were determined, the secondary polypeptide structure was found to contain several half-turns and 3 10 -helical segments, and a preliminary characterization of the overall polypeptide backbone fold in the β-domain containing the three-metal cluster, and the α-domain containing the four-metal cluster, was obtained. Using a new, more extensive set of nuclear magnetic resonance data these earlier structures were improved by new structure calculations. The new experimental data consist of distance constraints from measurements of nuclear Overhauser effects, and dihedral angle constraints derived from both coupling constants and nuclear Overhauser effects. The structure calculations were performed with the program DISMAN. Since no information on the orientation of the two domains relative to each other could be obtained, the structure calculations were performed separately for the α-domain and the β-domain. The average of the pairwise root-mean-square distances among the 20 structures with the least residual violations of input constraints was 2.9 Å for the β-domain and 1.4 Å for the a-domain (1 Å = 0.1 nm). The overall chirality of the polypeptide fold is right-handed for the β-domain and left-handed for the α-domain. For each of the seven metal ions the local chirality of the co-ordination of the four cysteinyl S γ atoms is clearly defined. The improved structures of both domains show the previously noted differences relative to the recently published crystal structure of metallothionein-2a from rat liver." @default.
• W2012190775 created "2016-06-24" @default.
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• W2012190775 date "1988-06-01" @default.
• W2012190775 modified "2023-10-03" @default.
• W2012190775 title "Three-dimensional structure of rabbit liver [Cd7]metallothionein-2a in aqueous solution determined by nuclear magnetic resonance" @default.
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• W2012190775 doi "https://doi.org/10.1016/0022-2836(88)90644-4" @default.
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