Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012191446> ?p ?o ?g. }
- W2012191446 endingPage "4310" @default.
- W2012191446 startingPage "4300" @default.
- W2012191446 abstract "Oxidative stress, lipid peroxidation, hyperglycemia‐induced glycations and environmental exposures increase the cellular concentrations of aldehydes. A novel aspect of the molecular actions of aldehydes, e.g. acetaldehyde and acrolein, is their reaction with the cysteine ligands of zinc sites in proteins and concomitant zinc release. Stoichiometric amounts of acrolein release zinc from zinc–thiolate coordination sites in proteins such as metallothionein and alcohol dehydrogenase. Aldehydes also release zinc intracellularly in cultured human hepatoma (HepG2) cells and interfere with zinc‐dependent signaling processes such as gene expression and phosphorylation. Thus both acetaldehyde and acrolein induce the expression of metallothionein and modulate protein tyrosine phosphatase activity in a zinc‐dependent way. Since minute changes in the availability of cellular zinc have potent effects, zinc release is a mechanism of amplification that may account for many of the biological effects of aldehydes. The zinc‐releasing activity of aldehydes establishes relationships among cellular zinc, the functions of endogenous and xenobiotic aldehydes, and redox stress, with implications for pathobiochemical and toxicologic mechanisms." @default.
- W2012191446 created "2016-06-24" @default.
- W2012191446 creator A5000431856 @default.
- W2012191446 creator A5089294941 @default.
- W2012191446 date "2006-08-23" @default.
- W2012191446 modified "2023-09-30" @default.
- W2012191446 title "Aldehydes release zinc from proteins. A pathway from oxidative stress/lipid peroxidation to cellular functions of zinc" @default.
- W2012191446 cites W1499097678 @default.
- W2012191446 cites W1508875207 @default.
- W2012191446 cites W1606569911 @default.
- W2012191446 cites W1612987016 @default.
- W2012191446 cites W164972547 @default.
- W2012191446 cites W1754980219 @default.
- W2012191446 cites W196233321 @default.
- W2012191446 cites W1966781309 @default.
- W2012191446 cites W1966855443 @default.
- W2012191446 cites W1967292684 @default.
- W2012191446 cites W1973924126 @default.
- W2012191446 cites W1975579571 @default.
- W2012191446 cites W1977000545 @default.
- W2012191446 cites W1981965642 @default.
- W2012191446 cites W1984513006 @default.
- W2012191446 cites W1990830736 @default.
- W2012191446 cites W1994151063 @default.
- W2012191446 cites W2001612481 @default.
- W2012191446 cites W2001778864 @default.
- W2012191446 cites W2002496210 @default.
- W2012191446 cites W2011316933 @default.
- W2012191446 cites W2012249270 @default.
- W2012191446 cites W2016070425 @default.
- W2012191446 cites W2022218526 @default.
- W2012191446 cites W2023137747 @default.
- W2012191446 cites W2026830944 @default.
- W2012191446 cites W2028732326 @default.
- W2012191446 cites W2046540215 @default.
- W2012191446 cites W2048896887 @default.
- W2012191446 cites W2052774926 @default.
- W2012191446 cites W2055498189 @default.
- W2012191446 cites W2056925277 @default.
- W2012191446 cites W2057522312 @default.
- W2012191446 cites W2060362359 @default.
- W2012191446 cites W2062382507 @default.
- W2012191446 cites W2064279444 @default.
- W2012191446 cites W2070049630 @default.
- W2012191446 cites W2082470605 @default.
- W2012191446 cites W2089587500 @default.
- W2012191446 cites W2097806194 @default.
- W2012191446 cites W2122680359 @default.
- W2012191446 cites W2126568409 @default.
- W2012191446 cites W2130122936 @default.
- W2012191446 cites W2132620218 @default.
- W2012191446 cites W2141605818 @default.
- W2012191446 cites W2143843694 @default.
- W2012191446 cites W2144175661 @default.
- W2012191446 cites W2147091482 @default.
- W2012191446 cites W2152656461 @default.
- W2012191446 cites W2156285040 @default.
- W2012191446 cites W2162184782 @default.
- W2012191446 cites W2210471762 @default.
- W2012191446 cites W2214671441 @default.
- W2012191446 cites W2254959160 @default.
- W2012191446 cites W241987236 @default.
- W2012191446 cites W4231376406 @default.
- W2012191446 cites W4237120149 @default.
- W2012191446 doi "https://doi.org/10.1111/j.1742-4658.2006.05428.x" @default.
- W2012191446 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16930132" @default.
- W2012191446 hasPublicationYear "2006" @default.
- W2012191446 type Work @default.
- W2012191446 sameAs 2012191446 @default.
- W2012191446 citedByCount "70" @default.
- W2012191446 countsByYear W20121914462012 @default.
- W2012191446 countsByYear W20121914462013 @default.
- W2012191446 countsByYear W20121914462014 @default.
- W2012191446 countsByYear W20121914462015 @default.
- W2012191446 countsByYear W20121914462016 @default.
- W2012191446 countsByYear W20121914462017 @default.
- W2012191446 countsByYear W20121914462018 @default.
- W2012191446 countsByYear W20121914462019 @default.
- W2012191446 countsByYear W20121914462020 @default.
- W2012191446 countsByYear W20121914462021 @default.
- W2012191446 countsByYear W20121914462022 @default.
- W2012191446 countsByYear W20121914462023 @default.
- W2012191446 crossrefType "journal-article" @default.
- W2012191446 hasAuthorship W2012191446A5000431856 @default.
- W2012191446 hasAuthorship W2012191446A5089294941 @default.
- W2012191446 hasConcept C161790260 @default.
- W2012191446 hasConcept C178790620 @default.
- W2012191446 hasConcept C181199279 @default.
- W2012191446 hasConcept C185592680 @default.
- W2012191446 hasConcept C20719415 @default.
- W2012191446 hasConcept C25747580 @default.
- W2012191446 hasConcept C2776151105 @default.
- W2012191446 hasConcept C2777344606 @default.
- W2012191446 hasConcept C2777595113 @default.
- W2012191446 hasConcept C2778290051 @default.
- W2012191446 hasConcept C2780161600 @default.
- W2012191446 hasConcept C2780422782 @default.
- W2012191446 hasConcept C2780829032 @default.