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- W2012191497 abstract "β-Caryophyllene (BCP), a natural bicyclic sesquiterpene present in several essential oils, displays analgesic and anti-inflammatory properties in vitro and in vivo. Astrocytes are a major class of glial cells that regulate extracellular ion balance, repair and scarring processes in the CNS following neuroinflammatory conditions and traumatic injuries. This study sought to determine the protective effect of BCP against glutamate (Glu)-induced cytotoxicity in the C6 glioma cell line on neurochemical parameters as well as their biochemical mechanism. Glu increases intracellular reactive oxygen species (ROS) production and induces mitochondrial dysfunction as well as decreasing antioxidant defenses such as glutathione (GSH) and glutathione peroxidase activity. BCP prevented C6 cells from Glu-induced cytotoxicity by modulating the cellular antioxidant response, mainly by inhibiting ROS production and reestablishing the mitochondrial membrane potential (Δψm). Moreover, BCP per se induced the nuclear translocation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) which was reflected by improvement in the cellular GSH antioxidant system. Taken together, our results suggest that cytoprotective effects of BCP were mediated by the amelioration of cellular antioxidant responses via Nrf2 activation, which is, in part, dependent on cannabinoid receptor type 2 (CB2R) activation. This functional nonpsychoactive CB2R ligand, could represent an important molecule for protection of glial cells against oxidative stress induced by glutamate." @default.
- W2012191497 created "2016-06-24" @default.
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- W2012191497 creator A5079922285 @default.
- W2012191497 date "2014-10-01" @default.
- W2012191497 modified "2023-10-06" @default.
- W2012191497 title "β-Caryophyllene protects the C6 glioma cells against glutamate-induced excitotoxicity through the Nrf2 pathway" @default.
- W2012191497 cites W1485009620 @default.
- W2012191497 cites W1498636565 @default.
- W2012191497 cites W1526037649 @default.
- W2012191497 cites W1599277155 @default.
- W2012191497 cites W1603938906 @default.
- W2012191497 cites W1963769931 @default.
- W2012191497 cites W1964293866 @default.
- W2012191497 cites W1965108122 @default.
- W2012191497 cites W1967157314 @default.
- W2012191497 cites W1970813260 @default.
- W2012191497 cites W1976696624 @default.
- W2012191497 cites W1977127420 @default.
- W2012191497 cites W1978569086 @default.
- W2012191497 cites W1978896829 @default.
- W2012191497 cites W1980608195 @default.
- W2012191497 cites W1982377058 @default.
- W2012191497 cites W1984678769 @default.
- W2012191497 cites W1984716386 @default.
- W2012191497 cites W1990216374 @default.
- W2012191497 cites W1992206604 @default.
- W2012191497 cites W1992792495 @default.
- W2012191497 cites W1992883702 @default.
- W2012191497 cites W1993688922 @default.
- W2012191497 cites W1993712340 @default.
- W2012191497 cites W1997464514 @default.
- W2012191497 cites W1998801948 @default.
- W2012191497 cites W2004913784 @default.
- W2012191497 cites W2005896958 @default.
- W2012191497 cites W2012851706 @default.
- W2012191497 cites W2016927879 @default.
- W2012191497 cites W2025945836 @default.
- W2012191497 cites W2026261400 @default.
- W2012191497 cites W2028331558 @default.
- W2012191497 cites W2028377920 @default.
- W2012191497 cites W2030508516 @default.
- W2012191497 cites W2032455969 @default.
- W2012191497 cites W2033211001 @default.
- W2012191497 cites W2041090873 @default.
- W2012191497 cites W2042142367 @default.
- W2012191497 cites W2043013675 @default.
- W2012191497 cites W2044063309 @default.
- W2012191497 cites W2045239637 @default.
- W2012191497 cites W2045836156 @default.
- W2012191497 cites W2048979963 @default.
- W2012191497 cites W2049287536 @default.
- W2012191497 cites W2049812302 @default.
- W2012191497 cites W2053318380 @default.
- W2012191497 cites W2058711992 @default.
- W2012191497 cites W2059969163 @default.
- W2012191497 cites W2061600370 @default.
- W2012191497 cites W2066557327 @default.
- W2012191497 cites W2068147651 @default.
- W2012191497 cites W2068997428 @default.
- W2012191497 cites W2077492907 @default.
- W2012191497 cites W2080907465 @default.
- W2012191497 cites W2082789655 @default.
- W2012191497 cites W2085061717 @default.
- W2012191497 cites W2087131420 @default.
- W2012191497 cites W2087941113 @default.
- W2012191497 cites W2089755573 @default.
- W2012191497 cites W2092545696 @default.
- W2012191497 cites W2094681500 @default.
- W2012191497 cites W2095019862 @default.
- W2012191497 cites W2097021021 @default.
- W2012191497 cites W2120959748 @default.
- W2012191497 cites W2126203280 @default.
- W2012191497 cites W2130698201 @default.
- W2012191497 cites W2139400382 @default.
- W2012191497 cites W2140553664 @default.
- W2012191497 cites W2142582331 @default.
- W2012191497 cites W2143425403 @default.
- W2012191497 cites W2145931936 @default.
- W2012191497 cites W2154568954 @default.
- W2012191497 cites W2155056654 @default.
- W2012191497 cites W2157199552 @default.
- W2012191497 cites W2161908794 @default.
- W2012191497 cites W2171742547 @default.
- W2012191497 cites W2184425084 @default.
- W2012191497 doi "https://doi.org/10.1016/j.neuroscience.2014.08.043" @default.
- W2012191497 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25194788" @default.
- W2012191497 hasPublicationYear "2014" @default.
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