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• W2012192297 endingPage "15" @default.
• W2012192297 startingPage "3" @default.
• W2012192297 abstract "A recent application of microdialysis is the introduction of a substance into the extracellular space via the microdialysis probe. The inclusion of a higher amount of a drug in the perfusate allows the drug to diffuse through the microdialysis membrane to the tissue. This technique, actually called as reverse microdialysis, not only allows the local administration of a substance but also permits the simultaneous sampling of the extracellular levels of endogenous compounds. Local effects of exogenous compounds have been studied in the central nervous system, hepatic tissue, dermis, heart and corpora luteae of experimental animals by means of reverse microdialysis. In central nervous studies, reverse microdialysis has been extensively used for the study of the effects on neurotransmission at different central nuclei of diverse pharmacological and toxicological agents, such as antidepressants, antipsychotics, antiparkinsonians, hallucinogens, drugs of abuse and experimental drugs. In the clinical setting, reverse microdialysis has been used for the study of local effects of drugs in the adipose tissue, skeletal muscle and dermis. The aim of this review is to describe the principles of the reverse microdialysis, to compare the technique with other available methods and finally to describe the applicability of reverse microdialysis in the study of drugs properties both in basic and clinical research." @default.
• W2012192297 created "2016-06-24" @default.
• W2012192297 creator A5001379512 @default.
• W2012192297 creator A5045403820 @default.
• W2012192297 creator A5063477355 @default.
• W2012192297 date "2007-01-01" @default.
• W2012192297 modified "2023-09-23" @default.
• W2012192297 title "Applicability of reverse microdialysis in pharmacological and toxicological studies" @default.
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• W2012192297 doi "https://doi.org/10.1016/j.vascn.2006.02.007" @default.
• W2012192297 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16567112" @default.
• W2012192297 hasPublicationYear "2007" @default.
• W2012192297 type Work @default.

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