Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012192811> ?p ?o ?g. }
- W2012192811 endingPage "16207" @default.
- W2012192811 startingPage "16194" @default.
- W2012192811 abstract "Densin is an abundant scaffold protein in the postsynaptic density (PSD) that forms a high-affinity complex with αCaMKII and α-actinin. To assess the function of densin, we created a mouse line with a null mutation in the gene encoding it (LRRC7). Homozygous knock-out mice display a wide variety of abnormal behaviors that are often considered endophenotypes of schizophrenia and autism spectrum disorders. At the cellular level, loss of densin results in reduced levels of α-actinin in the brain and selective reduction in the localization of mGluR5 and DISC1 in the PSD fraction, whereas the amounts of ionotropic glutamate receptors and other prominent PSD proteins are unchanged. In addition, deletion of densin results in impairment of mGluR- and NMDA receptor-dependent forms of long-term depression, alters the early dynamics of regulation of CaMKII by NMDA-type glutamate receptors, and produces a change in spine morphology. These results indicate that densin influences the function of mGluRs and CaMKII at synapses and contributes to localization of mGluR5 and DISC1 in the PSD fraction. They are consistent with the hypothesis that mutations that disrupt the organization and/or dynamics of postsynaptic signaling complexes in excitatory synapses can cause behavioral endophenotypes of mental illness." @default.
- W2012192811 created "2016-06-24" @default.
- W2012192811 creator A5003624509 @default.
- W2012192811 creator A5012897375 @default.
- W2012192811 creator A5019090318 @default.
- W2012192811 creator A5024026632 @default.
- W2012192811 creator A5024855512 @default.
- W2012192811 creator A5038953542 @default.
- W2012192811 creator A5044707276 @default.
- W2012192811 creator A5048832172 @default.
- W2012192811 creator A5057534772 @default.
- W2012192811 creator A5059465067 @default.
- W2012192811 creator A5059996026 @default.
- W2012192811 date "2011-11-09" @default.
- W2012192811 modified "2023-10-01" @default.
- W2012192811 title "Deletion of Densin-180 Results in Abnormal Behaviors Associated with Mental Illness and Reduces mGluR5 and DISC1 in the Postsynaptic Density Fraction" @default.
- W2012192811 cites W1487630095 @default.
- W2012192811 cites W1499993606 @default.
- W2012192811 cites W1895137842 @default.
- W2012192811 cites W1966673980 @default.
- W2012192811 cites W1966958204 @default.
- W2012192811 cites W1967716675 @default.
- W2012192811 cites W1970690750 @default.
- W2012192811 cites W1970918416 @default.
- W2012192811 cites W1983194657 @default.
- W2012192811 cites W1989879415 @default.
- W2012192811 cites W1992530750 @default.
- W2012192811 cites W1997956229 @default.
- W2012192811 cites W2006376420 @default.
- W2012192811 cites W2017197221 @default.
- W2012192811 cites W2028491630 @default.
- W2012192811 cites W2037247014 @default.
- W2012192811 cites W2043006474 @default.
- W2012192811 cites W2043335534 @default.
- W2012192811 cites W2053045480 @default.
- W2012192811 cites W2053698533 @default.
- W2012192811 cites W2056145172 @default.
- W2012192811 cites W2058172887 @default.
- W2012192811 cites W2059644034 @default.
- W2012192811 cites W2061893190 @default.
- W2012192811 cites W2062416387 @default.
- W2012192811 cites W2070501686 @default.
- W2012192811 cites W2074258117 @default.
- W2012192811 cites W2078391414 @default.
- W2012192811 cites W2080213202 @default.
- W2012192811 cites W2082845790 @default.
- W2012192811 cites W2085588350 @default.
- W2012192811 cites W2086578939 @default.
- W2012192811 cites W2086596085 @default.
- W2012192811 cites W2088937623 @default.
- W2012192811 cites W2095421300 @default.
- W2012192811 cites W2098261813 @default.
- W2012192811 cites W2098277878 @default.
- W2012192811 cites W2101764987 @default.
- W2012192811 cites W2102092558 @default.
- W2012192811 cites W2110374888 @default.
- W2012192811 cites W2114342445 @default.
- W2012192811 cites W2119383776 @default.
- W2012192811 cites W2119588953 @default.
- W2012192811 cites W2123128031 @default.
- W2012192811 cites W2127810309 @default.
- W2012192811 cites W2130196517 @default.
- W2012192811 cites W2135772494 @default.
- W2012192811 cites W2145768048 @default.
- W2012192811 cites W2146521940 @default.
- W2012192811 cites W2146738944 @default.
- W2012192811 cites W2152541148 @default.
- W2012192811 cites W2158350175 @default.
- W2012192811 cites W2160557453 @default.
- W2012192811 cites W2165324329 @default.
- W2012192811 cites W2168482896 @default.
- W2012192811 cites W4296759721 @default.
- W2012192811 doi "https://doi.org/10.1523/jneurosci.5877-10.2011" @default.
- W2012192811 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3235477" @default.
- W2012192811 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22072671" @default.
- W2012192811 hasPublicationYear "2011" @default.
- W2012192811 type Work @default.
- W2012192811 sameAs 2012192811 @default.
- W2012192811 citedByCount "62" @default.
- W2012192811 countsByYear W20121928112012 @default.
- W2012192811 countsByYear W20121928112013 @default.
- W2012192811 countsByYear W20121928112014 @default.
- W2012192811 countsByYear W20121928112015 @default.
- W2012192811 countsByYear W20121928112016 @default.
- W2012192811 countsByYear W20121928112017 @default.
- W2012192811 countsByYear W20121928112018 @default.
- W2012192811 countsByYear W20121928112019 @default.
- W2012192811 countsByYear W20121928112020 @default.
- W2012192811 countsByYear W20121928112021 @default.
- W2012192811 countsByYear W20121928112022 @default.
- W2012192811 countsByYear W20121928112023 @default.
- W2012192811 crossrefType "journal-article" @default.
- W2012192811 hasAuthorship W2012192811A5003624509 @default.
- W2012192811 hasAuthorship W2012192811A5012897375 @default.
- W2012192811 hasAuthorship W2012192811A5019090318 @default.
- W2012192811 hasAuthorship W2012192811A5024026632 @default.
- W2012192811 hasAuthorship W2012192811A5024855512 @default.
- W2012192811 hasAuthorship W2012192811A5038953542 @default.