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• W2012192893 abstract "Amphotericin B (AmB) is a well-known polyene macrolide antibiotic used to treat systemic fungal infections. AmB targets more efficiently fungal than animal membranes. However, there are only minor differences in the mode of action of AmB against both types of membranes, which is a source of AmB toxicity. In this work, we analyzed interactions of two low toxic derivatives of AmB (SAmE and PAmE), synthesized in our laboratory, with lipid membranes. Molecular dynamics simulations of the lipid bilayers containing ergosterol (fungal cells) or cholesterol (animal cells) and the studied antibiotic molecules were performed to compare the structural and dynamic properties of AmB derivatives and the parent drug inside the membrane. A number of differences was found for AmB and its derivatives' behavior in cholesterol- and ergosterol-containing membranes. We found that PAmE and SAmE can penetrate deeper into the hydrophobic region of the membrane compared to AmB. Modification of the amino and carboxyl group of AmB also resulted in the conformational transition within the antibiotic's polar head. Wobbling dynamics differentiation, depending on the sterol present, was discovered for the AmB derivatives. These differences may be interpreted as molecular factors responsible for the improved selectivity observed macroscopically for the studied AmB derivatives." @default.
• W2012192893 created "2016-06-24" @default.
• W2012192893 creator A5015406561 @default.
• W2012192893 creator A5050111942 @default.
• W2012192893 creator A5075050584 @default.
• W2012192893 date "2007-10-01" @default.
• W2012192893 modified "2023-09-27" @default.
• W2012192893 title "Interactions of amphotericin B derivatives with lipid membranes—A molecular dynamics study" @default.
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• W2012192893 doi "https://doi.org/10.1016/j.bbamem.2007.06.017" @default.
• W2012192893 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17662232" @default.
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