FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012193854> ?p ?o ?g. }

• W2012193854 endingPage "e18" @default.
• W2012193854 startingPage "e18" @default.
• W2012193854 abstract "Macrophages from C57BL/6J (B6) mice restrict growth of the intracellular bacterial pathogen Legionella pneumophila. Restriction of bacterial growth requires caspase-1 and the leucine-rich repeat-containing protein Naip5 (Birc1e). We identified mutants of L. pneumophila that evade macrophage innate immunity. All mutants were deficient in expression of flagellin, the primary flagellar subunit, and failed to induce caspase-1-mediated macrophage death. Interestingly, a previously isolated flagellar mutant (fliI) that expresses, but does not assemble, flagellin did not replicate in macrophages, and induced macrophage death. Thus, flagellin itself, not flagella or motility, is required to initiate macrophage innate immunity. Immunity to Legionella did not require MyD88, an essential adaptor for toll-like receptor 5 (TLR5) signaling. Moreover, flagellin of Legionella and Salmonella induced cytotoxicity when delivered to the macrophage cytosol using Escherichia coli as a heterologous host. It thus appears that macrophages sense cytosolic flagellin via a TLR5-independent pathway that leads to rapid caspase-1-dependent cell death and provides defense against intracellular bacterial pathogens." @default.
• W2012193854 created "2016-06-24" @default.
• W2012193854 creator A5040929986 @default.
• W2012193854 creator A5045955094 @default.
• W2012193854 creator A5048997184 @default.
• W2012193854 creator A5061473047 @default.
• W2012193854 creator A5080222404 @default.
• W2012193854 date "2006-03-17" @default.
• W2012193854 modified "2023-10-14" @default.
• W2012193854 title "Flagellin-Deficient Legionella Mutants Evade Caspase-1- and Naip5-Mediated Macrophage Immunity" @default.
• W2012193854 cites W1519633296 @default.
• W2012193854 cites W1529674879 @default.
• W2012193854 cites W1542922109 @default.
• W2012193854 cites W1671931635 @default.
• W2012193854 cites W1840817809 @default.
• W2012193854 cites W1909754684 @default.
• W2012193854 cites W1962145422 @default.
• W2012193854 cites W1964977785 @default.
• W2012193854 cites W1970935350 @default.
• W2012193854 cites W1970960991 @default.
• W2012193854 cites W1972093499 @default.
• W2012193854 cites W1975032025 @default.
• W2012193854 cites W1981783746 @default.
• W2012193854 cites W1986997900 @default.
• W2012193854 cites W1996729081 @default.
• W2012193854 cites W2008034134 @default.
• W2012193854 cites W2008261126 @default.
• W2012193854 cites W2016503643 @default.
• W2012193854 cites W2021387811 @default.
• W2012193854 cites W2022880109 @default.
• W2012193854 cites W2024746774 @default.
• W2012193854 cites W2033604879 @default.
• W2012193854 cites W2040024879 @default.
• W2012193854 cites W2040853949 @default.
• W2012193854 cites W2043667001 @default.
• W2012193854 cites W2044571296 @default.
• W2012193854 cites W2066904343 @default.
• W2012193854 cites W2066974855 @default.
• W2012193854 cites W2074747472 @default.
• W2012193854 cites W2075145828 @default.
• W2012193854 cites W2075583035 @default.
• W2012193854 cites W2077225605 @default.
• W2012193854 cites W2078254281 @default.
• W2012193854 cites W2095251670 @default.
• W2012193854 cites W2096915882 @default.
• W2012193854 cites W2097551453 @default.
• W2012193854 cites W2104416424 @default.
• W2012193854 cites W2107674270 @default.
• W2012193854 cites W2107983352 @default.
• W2012193854 cites W2111900042 @default.
• W2012193854 cites W2118904250 @default.
• W2012193854 cites W2125309974 @default.
• W2012193854 cites W2132482634 @default.
• W2012193854 cites W2136246773 @default.
• W2012193854 cites W2138507798 @default.
• W2012193854 cites W2147056690 @default.
• W2012193854 cites W2155795106 @default.
• W2012193854 cites W2157985992 @default.
• W2012193854 cites W2158771008 @default.
• W2012193854 cites W2168977023 @default.
• W2012193854 cites W348719356 @default.
• W2012193854 doi "https://doi.org/10.1371/journal.ppat.0020018" @default.
• W2012193854 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1401497" @default.
• W2012193854 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16552444" @default.
• W2012193854 hasPublicationYear "2006" @default.
• W2012193854 type Work @default.
• W2012193854 sameAs 2012193854 @default.
• W2012193854 citedByCount "487" @default.
• W2012193854 countsByYear W20121938542012 @default.
• W2012193854 countsByYear W20121938542013 @default.
• W2012193854 countsByYear W20121938542014 @default.
• W2012193854 countsByYear W20121938542015 @default.
• W2012193854 countsByYear W20121938542016 @default.
• W2012193854 countsByYear W20121938542017 @default.
• W2012193854 countsByYear W20121938542018 @default.
• W2012193854 countsByYear W20121938542019 @default.
• W2012193854 countsByYear W20121938542020 @default.
• W2012193854 countsByYear W20121938542021 @default.
• W2012193854 countsByYear W20121938542022 @default.
• W2012193854 countsByYear W20121938542023 @default.
• W2012193854 crossrefType "journal-article" @default.
• W2012193854 hasAuthorship W2012193854A5040929986 @default.
• W2012193854 hasAuthorship W2012193854A5045955094 @default.
• W2012193854 hasAuthorship W2012193854A5048997184 @default.
• W2012193854 hasAuthorship W2012193854A5061473047 @default.
• W2012193854 hasAuthorship W2012193854A5080222404 @default.
• W2012193854 hasBestOaLocation W20121938541 @default.
• W2012193854 hasConcept C136449434 @default.
• W2012193854 hasConcept C139964883 @default.
• W2012193854 hasConcept C170493617 @default.
• W2012193854 hasConcept C202751555 @default.
• W2012193854 hasConcept C203014093 @default.
• W2012193854 hasConcept C2776118409 @default.
• W2012193854 hasConcept C2776709828 @default.
• W2012193854 hasConcept C2777209026 @default.
• W2012193854 hasConcept C2777338127 @default.
• W2012193854 hasConcept C2779244956 @default.
• W2012193854 hasConcept C38117629 @default.

• next