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• W2012194375 abstract "No AccessJournal of UrologyINVESTIGATIVE UROLOGY1 Sep 2000CNS INDUCED NEUROGENIC CYSTITIS IS ASSOCIATED WITH BLADDER MAST CELL DEGRANULATION IN THE RAT LUC JASMIN, GABRIELLA JANNI, PETER T. OHARA, and SAMUEL D. RABKIN LUC JASMINLUC JASMIN More articles by this author , GABRIELLA JANNIGABRIELLA JANNI More articles by this author , PETER T. OHARAPETER T. OHARA More articles by this author , and SAMUEL D. RABKINSAMUEL D. RABKIN More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)67326-0AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: To determine if bladder mast cell degranulation is involved in the genesis of neurogenic cystitis induced by pseudorabies virus (PRV) invasion of the central nervous system (CNS). Materials and Methods: Rats received a total of 4 × 106 plaque forming units (pfu) of PRV-Bartha in the abductor caudalis dorsalis (ACD) muscle. Granulated bladder mast cells per mm2 of bladder tissue and urine histamine content were monitored as the cystitis developed over the next few days. In a subgroup of rats, intravesical resiniferatoxin was used to remove capsaicin-sensitive sensory bladder afferents, while another subgroup was pretreated with a mast cell degranulator. Results: PRV injection into the ACD muscle leads to neurogenic cystitis. Histamine levels were elevated in the urine of virus injected rats before any behavioral or microscopical signs of cystitis were present. When the cystitis became clinically manifest, urine histamine returned to control levels, and the number of granulated mast cells dropped significantly. Rats in which capsaicin-sensitive afferents had been removed did not show any signs of cystitis, or increase in urine histamine, or change in the number of granulated mast cells. Pretreatment of animals with a mast cell degranulator completely prevented the appearance of cystitis without altering the CNS disease. Conclusion: These results provide further evidence that mast cells are involved in neurogenic cystitis induced by changes in CNS activity. References 1 : Increased urine histamine and methylhistamine in interstitial cystitis. J Urol1994; 152: 350. Link, Google Scholar 2 : Mast cells in interstitial cystitis. Ann Urol1989; 23: 165. Google Scholar 3 : Histamine content and mast cell count of detrusor muscle in patients with interstitial cystitis and other types of chronic cystitis. Br J Urol1983; 55: 495. Google Scholar 4 : Interstitial cystitis: a neuroimmunoendocrine disorder. Ann N Y Acad Sci1998; 840: 619. 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Google Scholar From the Departments of Neurosurgery, Cell Biology, Microbiology & Immunology, Georgetown University Medical Center, Washington, District of Columbia, and the Department of Anatomy, University of California, San Francisco, California© 2000 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byRudick C, Pavlov V, Chen M and Klumpp D (2018) Gender Specific Pelvic Pain Severity in Neurogenic CystitisJournal of Urology, VOL. 187, NO. 2, (715-724), Online publication date: 1-Feb-2012.WESTROPP J and BUFFINGTON C (2018) IN VIVO MODELS OF INTERSTITIAL CYSTITISJournal of Urology, VOL. 167, NO. 2 Part 1, (694-702), Online publication date: 1-Feb-2002.Batler R, Sengupta S, Forrestal S, Schaeffer A and Klumpp D (2018) Mast Cell Activation Triggers a Urothelial Inflammatory Response Mediated by Tumor Necrosis Factor-αJournal of Urology, VOL. 168, NO. 2, (819-825), Online publication date: 1-Aug-2002.Weiss J (2018) PELVIC FLOOR MYOFASCIAL TRIGGER POINTS: MANUAL THERAPY FOR INTERSTITIAL CYSTITIS AND THE URGENCY-FREQUENCY SYNDROMEJournal of Urology, VOL. 166, NO. 6, (2226-2231), Online publication date: 1-Dec-2001. Volume 164Issue 3 Part 1September 2000Page: 852-855 Advertisement Copyright & Permissions© 2000 by American Urological Association, Inc.KeywordsurinehistaminedenervationcapsaicinPseudorabies virusMetricsAuthor Information LUC JASMIN More articles by this author GABRIELLA JANNI More articles by this author PETER T. OHARA More articles by this author SAMUEL D. RABKIN More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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