FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012195037> ?p ?o ?g. }

• W2012195037 endingPage "2735" @default.
• W2012195037 startingPage "2727" @default.
• W2012195037 abstract "Meprins α and β, a subgroup of zinc metalloproteinases belonging to the astacin family, are known to cleave components of the extracellular matrix, either during physiological remodeling or in pathological situations. In this study we present a new role for meprins in matrix assembly, namely the proteolytic processing of procollagens. Both meprins α and β release the N- and C-propeptides from procollagen III, with such processing events being critical steps in collagen fibril formation. In addition, both meprins cleave procollagen III at exactly the same site as the procollagen C-proteinases, including bone morphogenetic protein-1 (BMP-1) and other members of the tolloid proteinase family. Indeed, cleavage of procollagen III by meprins is more efficient than by BMP-1. In addition, unlike BMP-1, whose activity is stimulated by procollagen C-proteinase enhancer proteins (PCPEs), the activity of meprins on procollagen III is diminished by PCPE-1. Finally, following our earlier observations of meprin expression by human epidermal keratinocytes, meprin α is also shown to be expressed by human dermal fibroblasts. In the dermis of fibrotic skin (keloids), expression of meprin α increases and meprin β begins to be detected. Our study suggests that meprins could be important players in several remodeling processes involving collagen fiber deposition." @default.
• W2012195037 created "2016-06-24" @default.
• W2012195037 creator A5006549290 @default.
• W2012195037 creator A5020009807 @default.
• W2012195037 creator A5035389860 @default.
• W2012195037 creator A5049423085 @default.
• W2012195037 creator A5060091206 @default.
• W2012195037 creator A5063249836 @default.
• W2012195037 creator A5067018409 @default.
• W2012195037 creator A5068553618 @default.
• W2012195037 creator A5073470059 @default.
• W2012195037 creator A5078668459 @default.
• W2012195037 date "2010-12-01" @default.
• W2012195037 modified "2023-10-16" @default.
• W2012195037 title "Processing of Procollagen III by Meprins: New Players in Extracellular Matrix Assembly?" @default.
• W2012195037 cites W1517515485 @default.
• W2012195037 cites W1563393647 @default.
• W2012195037 cites W1964442282 @default.
• W2012195037 cites W1970846696 @default.
• W2012195037 cites W1978401953 @default.
• W2012195037 cites W1979615635 @default.
• W2012195037 cites W1981567427 @default.
• W2012195037 cites W1989091925 @default.
• W2012195037 cites W1992203325 @default.
• W2012195037 cites W1995518402 @default.
• W2012195037 cites W1997538331 @default.
• W2012195037 cites W2001614649 @default.
• W2012195037 cites W2010912389 @default.
• W2012195037 cites W2016683685 @default.
• W2012195037 cites W2032274963 @default.
• W2012195037 cites W2050264706 @default.
• W2012195037 cites W2061945526 @default.
• W2012195037 cites W2063003823 @default.
• W2012195037 cites W2070730866 @default.
• W2012195037 cites W2076947779 @default.
• W2012195037 cites W2077916606 @default.
• W2012195037 cites W2078661860 @default.
• W2012195037 cites W2083220586 @default.
• W2012195037 cites W2093395445 @default.
• W2012195037 cites W2101100934 @default.
• W2012195037 cites W2103113681 @default.
• W2012195037 cites W2107192682 @default.
• W2012195037 cites W2118038977 @default.
• W2012195037 cites W2130457780 @default.
• W2012195037 cites W2130669420 @default.
• W2012195037 cites W2155615188 @default.
• W2012195037 cites W2162767053 @default.
• W2012195037 doi "https://doi.org/10.1038/jid.2010.202" @default.
• W2012195037 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20631730" @default.
• W2012195037 hasPublicationYear "2010" @default.
• W2012195037 type Work @default.
• W2012195037 sameAs 2012195037 @default.
• W2012195037 citedByCount "84" @default.
• W2012195037 countsByYear W20121950372012 @default.
• W2012195037 countsByYear W20121950372013 @default.
• W2012195037 countsByYear W20121950372014 @default.
• W2012195037 countsByYear W20121950372015 @default.
• W2012195037 countsByYear W20121950372016 @default.
• W2012195037 countsByYear W20121950372017 @default.
• W2012195037 countsByYear W20121950372018 @default.
• W2012195037 countsByYear W20121950372019 @default.
• W2012195037 countsByYear W20121950372020 @default.
• W2012195037 countsByYear W20121950372021 @default.
• W2012195037 countsByYear W20121950372022 @default.
• W2012195037 countsByYear W20121950372023 @default.
• W2012195037 crossrefType "journal-article" @default.
• W2012195037 hasAuthorship W2012195037A5006549290 @default.
• W2012195037 hasAuthorship W2012195037A5020009807 @default.
• W2012195037 hasAuthorship W2012195037A5035389860 @default.
• W2012195037 hasAuthorship W2012195037A5049423085 @default.
• W2012195037 hasAuthorship W2012195037A5060091206 @default.
• W2012195037 hasAuthorship W2012195037A5063249836 @default.
• W2012195037 hasAuthorship W2012195037A5067018409 @default.
• W2012195037 hasAuthorship W2012195037A5068553618 @default.
• W2012195037 hasAuthorship W2012195037A5073470059 @default.
• W2012195037 hasAuthorship W2012195037A5078668459 @default.
• W2012195037 hasBestOaLocation W20121950371 @default.
• W2012195037 hasConcept C105702510 @default.
• W2012195037 hasConcept C109523444 @default.
• W2012195037 hasConcept C153911025 @default.
• W2012195037 hasConcept C185592680 @default.
• W2012195037 hasConcept C189165786 @default.
• W2012195037 hasConcept C2777624698 @default.
• W2012195037 hasConcept C28406088 @default.
• W2012195037 hasConcept C38008103 @default.
• W2012195037 hasConcept C55493867 @default.
• W2012195037 hasConcept C55728118 @default.
• W2012195037 hasConcept C64348721 @default.
• W2012195037 hasConcept C86803240 @default.
• W2012195037 hasConcept C95444343 @default.
• W2012195037 hasConceptScore W2012195037C105702510 @default.
• W2012195037 hasConceptScore W2012195037C109523444 @default.
• W2012195037 hasConceptScore W2012195037C153911025 @default.
• W2012195037 hasConceptScore W2012195037C185592680 @default.
• W2012195037 hasConceptScore W2012195037C189165786 @default.
• W2012195037 hasConceptScore W2012195037C2777624698 @default.
• W2012195037 hasConceptScore W2012195037C28406088 @default.
• W2012195037 hasConceptScore W2012195037C38008103 @default.

• next