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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012197859> ?p ?o ?g. }

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• W2012197859 abstract "The cyclin-dependent kinase 2 (cdk2) is a serine/threonine protein kinase that plays a key role in the cell cycle control system of all eukaryotic organisms. It has been a much studied drug target for potential anticancer therapy. Most cdk2 inhibitors in clinical development target almost exclusively the catalytic ATP-binding pocket of cdk2. However, several five amino-acid peptide inhibitors that are directed towards a noncatalytic binding pocket of cdk2 are reported here. Upon binding to this new pocket located at the cdk2 and cyclin interface, these peptide inhibitors are found to disrupt the cdk2/cyclin E complex partially and diminish its kinase activity in vitro." @default.
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• W2012197859 date "2009-01-01" @default.
• W2012197859 modified "2023-09-24" @default.
• W2012197859 title "A novel binding pocket of cyclin-dependent kinase 2" @default.
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• W2012197859 doi "https://doi.org/10.1002/prot.22136" @default.
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