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- W2012197880 abstract "Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are long chain omega 3 fatty acids which are thought to promote vascular health though anti-inflammatory and anti-atherosclerotic plaque mechanisms. MRI derived white matter hyperintensities are considered evidence of small vessel cerebrovascular disease, which may increase risk for cognitive decline. A cross-sectional study of plasma omega 3 fatty acid levels and MRI derived white matter hyperintensity (WMH) brain volumes was conducted in 40 community dwelling participants (aged 85 - 101 years) in the Oregon Brain Aging Study (OBAS). The average fasting period before blood draw was 3 hours and MRI was conducted within 1-month proximity to the blood collection. Plasma fatty acids were determined with the use of gas chromatography equipped with flame ionization detector. REGION image analysis software was used for total WMH volume quantification. Multivariate regression analyses were performed to assess the relationship between plasma DHA and EPA with WMH volumes. Subjects were mean age 93 (± 3.8) years, 28 (70%) were women, and 5% were carrying an ApoE-e4 allele. Average MMSE score was 27 (± 3). Log plasma DHA and EPA content were both significantly, inversely associated with WMH after adjustment for age, gender, education, ApoE - ∊4 genotype, BMI, blood pressure, creatinine, fasting duration, MMSE, Hachinski ischemic score, and intracranial volume (DHA, p = .009, EPA, p = .017). DHA and EPA association with WMH was maintained after further adjustment for other vascular risk factors including plasma total cholesterol, LDL, and homocysteine (DHA, p = .006; EPA, p = .017). Both plasma DHA and EPA have strong inverse associations with white matter hyperintensities in the oldest old. This relationship is independent of other established vascular risk factors, including blood pressure, lipid profile and plasma homocysteine. These data suggest that these long-chain, highly unsaturated omega 3 fatty acids may offer cerebrovascular protection in addition to other established risk factors." @default.
- W2012197880 created "2016-06-24" @default.
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- W2012197880 date "2010-07-01" @default.
- W2012197880 modified "2023-09-27" @default.
- W2012197880 title "P2-413: Association of plasma marine omega-3 fatty acids with white matter hyperintensities in the oldest old" @default.
- W2012197880 doi "https://doi.org/10.1016/j.jalz.2010.05.1466" @default.
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