FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012200981> ?p ?o ?g. }

• W2012200981 endingPage "90" @default.
• W2012200981 startingPage "84" @default.
• W2012200981 abstract "This study reports an assessment of a method of intestinal protection by the intraluminal administration of an oxygenated perfluorochemical, perfluorotributylamine, or gaseous oxygen in an attempt to provide oxygen for mucosal cells rendered ischemia. A model of acute arterial or acute arteriovenous ischemia was produced in adult female rats. All control ischemic animals died within 12 hours. To assess intestinal protection, the mortality rates in the experimental groups were compared with the 100 percent control mortality. Gaseous oxygen and oxygenated perfluorochemical administered intraluminally reduced mortality significantly in the acute arterial model but not in rats with arteriovenous occlusion. Electron microscopy demonstrated preservation of villi after 1 and 2 hours of occlusion in the oxygen-treated groups. Light microscopy revealed massive destruction in control animals with preserved architecture in both the gaseous oxygen and oxygenated perfluorochemical groups. These results demonstrate that the intraluminal delivery of oxygen to bowel rendered ischemic by arterial occlusion may significantly decrease anatomic bowel disruption and improve animal survival. Such techniques have a potential clinical application to facilitate salvage of ischemic intestine and to augment intestinal preservation. This study reports an assessment of a method of intestinal protection by the intraluminal administration of an oxygenated perfluorochemical, perfluorotributylamine, or gaseous oxygen in an attempt to provide oxygen for mucosal cells rendered ischemia. A model of acute arterial or acute arteriovenous ischemia was produced in adult female rats. All control ischemic animals died within 12 hours. To assess intestinal protection, the mortality rates in the experimental groups were compared with the 100 percent control mortality. Gaseous oxygen and oxygenated perfluorochemical administered intraluminally reduced mortality significantly in the acute arterial model but not in rats with arteriovenous occlusion. Electron microscopy demonstrated preservation of villi after 1 and 2 hours of occlusion in the oxygen-treated groups. Light microscopy revealed massive destruction in control animals with preserved architecture in both the gaseous oxygen and oxygenated perfluorochemical groups. These results demonstrate that the intraluminal delivery of oxygen to bowel rendered ischemic by arterial occlusion may significantly decrease anatomic bowel disruption and improve animal survival. Such techniques have a potential clinical application to facilitate salvage of ischemic intestine and to augment intestinal preservation." @default.
• W2012200981 created "2016-06-24" @default.
• W2012200981 creator A5017065065 @default.
• W2012200981 creator A5052351878 @default.
• W2012200981 creator A5067863185 @default.
• W2012200981 date "1985-01-01" @default.
• W2012200981 modified "2023-09-27" @default.
• W2012200981 title "Intestinal ischemia: Reduction of mortality utilizing intraluminal perfluorochemical" @default.
• W2012200981 cites W155504355 @default.
• W2012200981 cites W1971505965 @default.
• W2012200981 cites W1983122843 @default.
• W2012200981 cites W2024115932 @default.
• W2012200981 doi "https://doi.org/10.1016/s0002-9610(85)80014-3" @default.
• W2012200981 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3966645" @default.
• W2012200981 hasPublicationYear "1985" @default.
• W2012200981 type Work @default.
• W2012200981 sameAs 2012200981 @default.
• W2012200981 citedByCount "45" @default.
• W2012200981 countsByYear W20122009812012 @default.
• W2012200981 countsByYear W20122009812022 @default.
• W2012200981 crossrefType "journal-article" @default.
• W2012200981 hasAuthorship W2012200981A5017065065 @default.
• W2012200981 hasAuthorship W2012200981A5052351878 @default.
• W2012200981 hasAuthorship W2012200981A5067863185 @default.
• W2012200981 hasConcept C126322002 @default.
• W2012200981 hasConcept C141071460 @default.
• W2012200981 hasConcept C164705383 @default.
• W2012200981 hasConcept C178790620 @default.
• W2012200981 hasConcept C185592680 @default.
• W2012200981 hasConcept C2776268601 @default.
• W2012200981 hasConcept C2780114680 @default.
• W2012200981 hasConcept C2910951933 @default.
• W2012200981 hasConcept C3019368612 @default.
• W2012200981 hasConcept C42219234 @default.
• W2012200981 hasConcept C540031477 @default.
• W2012200981 hasConcept C541997718 @default.
• W2012200981 hasConcept C71924100 @default.
• W2012200981 hasConceptScore W2012200981C126322002 @default.
• W2012200981 hasConceptScore W2012200981C141071460 @default.
• W2012200981 hasConceptScore W2012200981C164705383 @default.
• W2012200981 hasConceptScore W2012200981C178790620 @default.
• W2012200981 hasConceptScore W2012200981C185592680 @default.
• W2012200981 hasConceptScore W2012200981C2776268601 @default.
• W2012200981 hasConceptScore W2012200981C2780114680 @default.
• W2012200981 hasConceptScore W2012200981C2910951933 @default.
• W2012200981 hasConceptScore W2012200981C3019368612 @default.
• W2012200981 hasConceptScore W2012200981C42219234 @default.
• W2012200981 hasConceptScore W2012200981C540031477 @default.
• W2012200981 hasConceptScore W2012200981C541997718 @default.
• W2012200981 hasConceptScore W2012200981C71924100 @default.
• W2012200981 hasIssue "1" @default.
• W2012200981 hasLocation W20122009811 @default.
• W2012200981 hasLocation W20122009812 @default.
• W2012200981 hasOpenAccess W2012200981 @default.
• W2012200981 hasPrimaryLocation W20122009811 @default.
• W2012200981 hasRelatedWork W1127532827 @default.
• W2012200981 hasRelatedWork W2045441736 @default.
• W2012200981 hasRelatedWork W2359613699 @default.
• W2012200981 hasRelatedWork W2392012757 @default.
• W2012200981 hasRelatedWork W2393809107 @default.
• W2012200981 hasRelatedWork W2434740212 @default.
• W2012200981 hasRelatedWork W2916957241 @default.
• W2012200981 hasRelatedWork W4210314798 @default.
• W2012200981 hasRelatedWork W4212775298 @default.
• W2012200981 hasRelatedWork W2131834918 @default.
• W2012200981 hasVolume "149" @default.
• W2012200981 isParatext "false" @default.
• W2012200981 isRetracted "false" @default.
• W2012200981 magId "2012200981" @default.
• W2012200981 workType "article" @default.