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- W2012201654 abstract "There has been a weak recommendation for routine genetic and Platelet function testing by the American college of cardiologists (ACC) for patients receiving clopidogrel. To investigate the variability in PFT response to CYP2C19 polymorphism and conduct a cost analysis. Eighty six Saudi patients who were stable on 75 mg clopidogrel at least for one month for various cardiac indications were enrolled. Genotyping by real-time polymerase chain reaction (PCR) and PFT was carried out (Verify Now P2Y12) for all the patients. Fifty three patients presented with the wild variant 1/1, 13 patients with 1/2, and 20 patients with 2/2. We could not detect allele 3 probably as our sample was small. There is a significant association between different genotyping and the percentage of inhibition ( P = 0.0002). 1/1 patients tend to be moderate-to-extensive metabolizers, whereas the majority of the rest are slow metabolizers. Forty eight patients presented with no symptoms suggestive for atherothrombotic events, and the rest complained of non-specific symptoms. Interestingly, proton-pump inhibitors, mainly Omeprazole, did not affect the overall rate of inhibition ( P = 0.60). The cost of doing the PFT is 250 SR/ patient and 200 SR/patient (real-time PCR) for kits and materials excluding equipments and labors. Equipments may change considerably according to the purchased technology. The PFT varied significantly according to the polymorphism. The cost of PFT and or genotyping is reasonable if the equipments are accessible." @default.
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- W2012201654 date "2013-04-01" @default.
- W2012201654 modified "2023-09-23" @default.
- W2012201654 title "The impact of CYP2C19 polymorphism on platelet reactivity for guiding clopidogrel treatment and cost analysis" @default.
- W2012201654 doi "https://doi.org/10.1016/j.jsha.2013.03.005" @default.
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