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- W2012201952 abstract "Mitochondrial DNA deletions, which are often flanked by repeats, are found in elderly organisms of many species. In this article, I describe the analysis of the mitochondrial genomes of 61 mammalian species and show that the number of the longer repeats constrains the typical life span. I also show that the number of repeats that occur in randomly shuffled sequences is a rough lower limit to the number in the actual sequences. These two constraints imply a maximum life expectancy for mammals of 80–100 years." @default.
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- W2012201952 date "2004-05-01" @default.
- W2012201952 modified "2023-09-30" @default.
- W2012201952 title "Mitochondrial DNA repeats constrain the life span of mammals" @default.
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- W2012201952 doi "https://doi.org/10.1016/j.tig.2004.03.003" @default.
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