Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012202122> ?p ?o ?g. }
- W2012202122 endingPage "73" @default.
- W2012202122 startingPage "63" @default.
- W2012202122 abstract "During early mouse embryogenesis, multiple patterning and differentiation events require the activity of Nodal, a ligand of the transforming growth factor-beta (TGFβ) family. Although Nodal signaling is known to require activity of EGF-CFC co-receptors in many contexts, it has been unclear whether all Nodal signaling in the early mouse embryo is EGF-CFC dependent. We have investigated the double null mutant phenotypes for the EGF-CFC genes Cripto and Cryptic, which encode co-receptors for Nodal, and have found that they have partially redundant functions in early mouse development. Expression of Cripto and Cryptic is non-overlapping prior to gastrulation, since Cripto is expressed solely in the epiblast whereas Cryptic is expressed in the primitive endoderm of the late blastocyst and the visceral endoderm after implantation. Despite these non-overlapping expression patterns, Cripto; Cryptic double mutants display severe defects in epiblast, extraembryonic ectoderm, and anterior visceral endoderm (AVE), resulting in phenotypes that are highly similar to those of Nodal null mutants. Our results indicate that both Cripto and Cryptic function non-cell-autonomously during normal development, and that most if not all Nodal activity in early mouse embryogenesis is EGF-CFC-dependent." @default.
- W2012202122 created "2016-06-24" @default.
- W2012202122 creator A5025125161 @default.
- W2012202122 creator A5040725924 @default.
- W2012202122 date "2010-06-01" @default.
- W2012202122 modified "2023-10-14" @default.
- W2012202122 title "Functional redundancy of EGF-CFC genes in epiblast and extraembryonic patterning during early mouse embryogenesis" @default.
- W2012202122 cites W1513929030 @default.
- W2012202122 cites W1515719112 @default.
- W2012202122 cites W1680418198 @default.
- W2012202122 cites W1959009706 @default.
- W2012202122 cites W1964691304 @default.
- W2012202122 cites W1966300079 @default.
- W2012202122 cites W1967071065 @default.
- W2012202122 cites W1967672250 @default.
- W2012202122 cites W1970519791 @default.
- W2012202122 cites W1972666776 @default.
- W2012202122 cites W1974222518 @default.
- W2012202122 cites W1979981202 @default.
- W2012202122 cites W1984727408 @default.
- W2012202122 cites W1989874642 @default.
- W2012202122 cites W1994144105 @default.
- W2012202122 cites W1995473388 @default.
- W2012202122 cites W1995798426 @default.
- W2012202122 cites W2003267140 @default.
- W2012202122 cites W2008777486 @default.
- W2012202122 cites W2017952840 @default.
- W2012202122 cites W2019186187 @default.
- W2012202122 cites W2019598289 @default.
- W2012202122 cites W2020798714 @default.
- W2012202122 cites W2022005838 @default.
- W2012202122 cites W2022272303 @default.
- W2012202122 cites W2022282055 @default.
- W2012202122 cites W2041573813 @default.
- W2012202122 cites W2044240582 @default.
- W2012202122 cites W2045523681 @default.
- W2012202122 cites W2049884609 @default.
- W2012202122 cites W2051433930 @default.
- W2012202122 cites W2056872760 @default.
- W2012202122 cites W2059119760 @default.
- W2012202122 cites W2060928558 @default.
- W2012202122 cites W2065546801 @default.
- W2012202122 cites W2067163479 @default.
- W2012202122 cites W2067916728 @default.
- W2012202122 cites W2069693786 @default.
- W2012202122 cites W2070539534 @default.
- W2012202122 cites W2071353985 @default.
- W2012202122 cites W2071981231 @default.
- W2012202122 cites W2073995152 @default.
- W2012202122 cites W2080342872 @default.
- W2012202122 cites W2082955515 @default.
- W2012202122 cites W2083664734 @default.
- W2012202122 cites W2084105838 @default.
- W2012202122 cites W2086490532 @default.
- W2012202122 cites W2090260381 @default.
- W2012202122 cites W2090697432 @default.
- W2012202122 cites W2092778272 @default.
- W2012202122 cites W2094145003 @default.
- W2012202122 cites W2095762981 @default.
- W2012202122 cites W2100705570 @default.
- W2012202122 cites W2103256978 @default.
- W2012202122 cites W2104633606 @default.
- W2012202122 cites W2106966136 @default.
- W2012202122 cites W2107141327 @default.
- W2012202122 cites W2108946209 @default.
- W2012202122 cites W2109379227 @default.
- W2012202122 cites W2110398378 @default.
- W2012202122 cites W2121777986 @default.
- W2012202122 cites W2131037997 @default.
- W2012202122 cites W2132488261 @default.
- W2012202122 cites W2133141201 @default.
- W2012202122 cites W2139684609 @default.
- W2012202122 cites W2141148392 @default.
- W2012202122 cites W2142482111 @default.
- W2012202122 cites W2142672099 @default.
- W2012202122 cites W2150163104 @default.
- W2012202122 cites W2158544588 @default.
- W2012202122 cites W2161821489 @default.
- W2012202122 cites W2161949020 @default.
- W2012202122 cites W2165040677 @default.
- W2012202122 cites W2166658859 @default.
- W2012202122 cites W2167513144 @default.
- W2012202122 cites W2186920803 @default.
- W2012202122 cites W2188179251 @default.
- W2012202122 cites W98546936 @default.
- W2012202122 doi "https://doi.org/10.1016/j.ydbio.2010.03.009" @default.
- W2012202122 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2866749" @default.
- W2012202122 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20346354" @default.
- W2012202122 hasPublicationYear "2010" @default.
- W2012202122 type Work @default.
- W2012202122 sameAs 2012202122 @default.
- W2012202122 citedByCount "33" @default.
- W2012202122 countsByYear W20122021222012 @default.
- W2012202122 countsByYear W20122021222013 @default.
- W2012202122 countsByYear W20122021222014 @default.
- W2012202122 countsByYear W20122021222015 @default.
- W2012202122 countsByYear W20122021222016 @default.
- W2012202122 countsByYear W20122021222017 @default.