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• W2012203474 endingPage "1297" @default.
• W2012203474 startingPage "1283" @default.
• W2012203474 abstract "The annual incidence of acute hepatitis C virus (HCV) has fallen in recent years, primarily because of effective blood screening efforts and increased education on the dangers of needle sharing. However, hepatitis C infection is still relatively frequent in certain populations. Most patients infected with HCV are unaware of their exposure and remain asymptomatic during the initial stages of the infection, making early diagnosis during the acute phase (first 6 months after infection) unlikely. While some of those infections will have a spontaneous resolution, the majority will progress to chronic HCV. We scanned the literature for predictors of spontaneous resolution and treatment during the acute stage of HCV to identify factors that would assist in treatment decision making.A medical literature search through MEDLINE was conducted using the keyword acute hepatitis C with a variety of keywords focused on (a) epidemiology, (b) natural history and outcome, (c) diagnosis, (d) mode of transmission, and (e) treatment.There are no reliable predictors for spontaneous resolution of HCV infection and a significant percentage of individuals exposed to HCV develop persistent infections that progress to chronic liver disease. An intriguing approach is to treat acute HCV and prevent the development of chronic hepatitis. Several clinical trials showed that treatment of hepatitis C infection during the acute phase is associated with high sustained virological response (SVR) rates ranging between 75% and 100%. Although there is a prevailing consensus that intervention during the acute phase is associated with improved viral eradication, relevant clinical questions have remained unanswered by clinical trials. Optimization of therapy for acute hepatitis C infection and identification of predictors of SVR represent a real challenge.With more than 170 million chronic hepatitis C patients worldwide and an increase in the related morbidity and mortality projected for the next decade, an improvement in our ability to diagnose and treat patients with acute hepatitis C would have a significant impact on the prevalence of chronic hepatitis and its associated complications particularly in countries with a high endemic background of the infection." @default.
• W2012203474 created "2016-06-24" @default.
• W2012203474 creator A5023115975 @default.
• W2012203474 date "2008-05-01" @default.
• W2012203474 modified "2023-10-15" @default.
• W2012203474 title "Acute Hepatitis C: A Systematic Review." @default.
• W2012203474 cites W1505139021 @default.
• W2012203474 cites W1522639724 @default.
• W2012203474 cites W1539273869 @default.
• W2012203474 cites W1562544358 @default.
• W2012203474 cites W1874253413 @default.
• W2012203474 cites W1967502745 @default.
• W2012203474 cites W1970844456 @default.
• W2012203474 cites W1978606949 @default.
• W2012203474 cites W1978783755 @default.
• W2012203474 cites W1980594671 @default.
• W2012203474 cites W1981108939 @default.
• W2012203474 cites W1983969325 @default.
• W2012203474 cites W1984746986 @default.
• W2012203474 cites W1985982900 @default.
• W2012203474 cites W1989058813 @default.
• W2012203474 cites W1989874976 @default.
• W2012203474 cites W1991020851 @default.
• W2012203474 cites W1994923672 @default.
• W2012203474 cites W1996810729 @default.
• W2012203474 cites W1999004738 @default.
• W2012203474 cites W2003127094 @default.
• W2012203474 cites W2008952561 @default.
• W2012203474 cites W2014254819 @default.
• W2012203474 cites W2014472957 @default.
• W2012203474 cites W2017796419 @default.
• W2012203474 cites W2021951172 @default.
• W2012203474 cites W2022445931 @default.
• W2012203474 cites W2039383406 @default.
• W2012203474 cites W2042272201 @default.
• W2012203474 cites W2043737127 @default.
• W2012203474 cites W2046387376 @default.
• W2012203474 cites W2046769266 @default.
• W2012203474 cites W2052981247 @default.
• W2012203474 cites W2058720438 @default.
• W2012203474 cites W2059022314 @default.
• W2012203474 cites W2059641736 @default.
• W2012203474 cites W2062395204 @default.
• W2012203474 cites W2062660860 @default.
• W2012203474 cites W2062672349 @default.
• W2012203474 cites W2064734074 @default.
• W2012203474 cites W2068970299 @default.
• W2012203474 cites W2069619392 @default.
• W2012203474 cites W2075480969 @default.
• W2012203474 cites W2076559408 @default.
• W2012203474 cites W2080416536 @default.
• W2012203474 cites W2082446768 @default.
• W2012203474 cites W2089014716 @default.
• W2012203474 cites W2089027304 @default.
• W2012203474 cites W2089968501 @default.
• W2012203474 cites W2094008852 @default.
• W2012203474 cites W2094416250 @default.
• W2012203474 cites W2097603150 @default.
• W2012203474 cites W2098618513 @default.
• W2012203474 cites W2100994154 @default.
• W2012203474 cites W2101502733 @default.
• W2012203474 cites W2101832306 @default.
• W2012203474 cites W2103638317 @default.
• W2012203474 cites W2105008918 @default.
• W2012203474 cites W2106791445 @default.
• W2012203474 cites W2108138167 @default.
• W2012203474 cites W2108972940 @default.
• W2012203474 cites W2109191005 @default.
• W2012203474 cites W2111044696 @default.
• W2012203474 cites W2111359040 @default.
• W2012203474 cites W2113729156 @default.
• W2012203474 cites W2120479348 @default.
• W2012203474 cites W2122049929 @default.
• W2012203474 cites W2126506419 @default.
• W2012203474 cites W2128428904 @default.
• W2012203474 cites W2129048530 @default.
• W2012203474 cites W2130259551 @default.
• W2012203474 cites W2134124890 @default.
• W2012203474 cites W2134673674 @default.
• W2012203474 cites W2137929296 @default.
• W2012203474 cites W2142492514 @default.
• W2012203474 cites W2143027385 @default.
• W2012203474 cites W2145623055 @default.
• W2012203474 cites W2146127612 @default.
• W2012203474 cites W2154628753 @default.
• W2012203474 cites W2157131507 @default.
• W2012203474 cites W2159974321 @default.
• W2012203474 cites W2161147764 @default.
• W2012203474 cites W2162587943 @default.
• W2012203474 cites W2261053110 @default.
• W2012203474 cites W2267762958 @default.
• W2012203474 cites W2413145541 @default.
• W2012203474 cites W2740336755 @default.
• W2012203474 cites W2921726982 @default.
• W2012203474 cites W4243775790 @default.
• W2012203474 cites W4247388329 @default.
• W2012203474 cites W4249706234 @default.
• W2012203474 cites W69879529 @default.

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