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• W2012203927 abstract "Circulating B-cell precursors specific for rheumatoid factor (RF) are present in normal subjects but spontaneous in vitro synthesis of RF occurs only in rheumatoid arthritis (RA). The regulatory role of RF-specific suppressor T cells in this process was studied in pokeweed mitogen-stimulated in vitro cultures of peripheral blood mononuclear cells. Addition of graded numbers of suppressor T8(+) cells from RA patients to normal B cells resulted in consistently less suppression of IgM and RF synthesis than that achieved by normal suppressor T cells. A preculture system was then used to probe for RF-specific suppressor precursor lymphocytes. RA T-cell populations failed to generate normal levels of RF-specific suppression during in vitro culture for 4 days. Incubation with human-aggregated IgG (HaIgG) resulted in an increase in RF-specific suppression to normal levels. The data indicate that induction and full expression of RF-specific suppressor T-cell function is blocked in vivo in RA but can be overcome in vitro by incubation with HaIgG." @default.
• W2012203927 created "2016-06-24" @default.
• W2012203927 creator A5035534167 @default.
• W2012203927 creator A5083095361 @default.
• W2012203927 date "1987-01-01" @default.
• W2012203927 modified "2023-09-25" @default.
• W2012203927 title "Decreased T-cell-mediated suppression of IgM-rheumatoid factor synthesis in rheumatoid arthritis" @default.
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• W2012203927 doi "https://doi.org/10.1016/0090-1229(87)90171-1" @default.
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