FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012204399> ?p ?o ?g. }

• W2012204399 endingPage "410" @default.
• W2012204399 startingPage "404" @default.
• W2012204399 abstract "The elucidation of the genetic control of susceptibility to common infectious diseases is expected to provide new and more effective tools for prevention and control of some of the most pressings health needs on a global scale. A major advantage of whole genome based genetic approaches is that no a priori assumptions about mechanisms of pathogenesis need to be made in these studies. Hence, genetic studies can identify previously unrecognized pathways of disease susceptibility and tag critical pathogenic events for further biochemical, immunological or physiological analysis. We have applied this strategy to leprosy, a disease that still claims 400,000 new cases each year. We identified genetic variants in the shared promoter region of the PARK2 and PACRG genes as major risk factors of leprosy susceptibility. Both encoded proteins are part of the cellular ubiquitination system. Specifically, PARK2, the cause of early onset Parkinson's disease, is an E3 ligase that likely is involved in controlled proteolysis, the cellular anti-oxidants response and the regulation of innate immune responsiveness. In addition, numerous E3 ligases have recently been shown to be critical regulators of immunity. While the specific role of PARK2/PACRG in leprosy pathogenesis remains unknown, a number of experimentally testable scenarios can be developed to further explore the role of these proteins in anti-Mycobacterium leprae host responsiveness." @default.
• W2012204399 created "2016-06-24" @default.
• W2012204399 creator A5037598943 @default.
• W2012204399 creator A5037740355 @default.
• W2012204399 creator A5071983807 @default.
• W2012204399 creator A5090497008 @default.
• W2012204399 date "2006-12-01" @default.
• W2012204399 modified "2023-10-11" @default.
• W2012204399 title "Genetic predisposition to leprosy: A major gene reveals novel pathways of immunity to Mycobacterium leprae" @default.
• W2012204399 cites W1526301924 @default.
• W2012204399 cites W1550876205 @default.
• W2012204399 cites W1592370692 @default.
• W2012204399 cites W1621213248 @default.
• W2012204399 cites W1796702517 @default.
• W2012204399 cites W1869741621 @default.
• W2012204399 cites W1877873625 @default.
• W2012204399 cites W1896814139 @default.
• W2012204399 cites W1963897814 @default.
• W2012204399 cites W1977898770 @default.
• W2012204399 cites W1981536452 @default.
• W2012204399 cites W1986706236 @default.
• W2012204399 cites W1992185401 @default.
• W2012204399 cites W1993927129 @default.
• W2012204399 cites W1994415651 @default.
• W2012204399 cites W1995651325 @default.
• W2012204399 cites W1999869434 @default.
• W2012204399 cites W2001941204 @default.
• W2012204399 cites W2004821943 @default.
• W2012204399 cites W2005935256 @default.
• W2012204399 cites W2010087601 @default.
• W2012204399 cites W2013846360 @default.
• W2012204399 cites W2018867789 @default.
• W2012204399 cites W2020709512 @default.
• W2012204399 cites W2027011292 @default.
• W2012204399 cites W2027329377 @default.
• W2012204399 cites W2040211909 @default.
• W2012204399 cites W2044835905 @default.
• W2012204399 cites W2045277217 @default.
• W2012204399 cites W2055124287 @default.
• W2012204399 cites W2056402897 @default.
• W2012204399 cites W2056715659 @default.
• W2012204399 cites W2057969646 @default.
• W2012204399 cites W2059761005 @default.
• W2012204399 cites W2068114378 @default.
• W2012204399 cites W2082305090 @default.
• W2012204399 cites W2097062199 @default.
• W2012204399 cites W2103022330 @default.
• W2012204399 cites W2105669755 @default.
• W2012204399 cites W2105970121 @default.
• W2012204399 cites W2109541288 @default.
• W2012204399 cites W2111682630 @default.
• W2012204399 cites W2113120391 @default.
• W2012204399 cites W2121144115 @default.
• W2012204399 cites W2124311371 @default.
• W2012204399 cites W2128071987 @default.
• W2012204399 cites W2145371252 @default.
• W2012204399 cites W2152664025 @default.
• W2012204399 cites W2158259597 @default.
• W2012204399 cites W2164217177 @default.
• W2012204399 cites W2166263915 @default.
• W2012204399 cites W2166987747 @default.
• W2012204399 cites W2171382646 @default.
• W2012204399 cites W4211207211 @default.
• W2012204399 cites W4239089206 @default.
• W2012204399 doi "https://doi.org/10.1016/j.smim.2006.07.005" @default.
• W2012204399 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16973374" @default.
• W2012204399 hasPublicationYear "2006" @default.
• W2012204399 type Work @default.
• W2012204399 sameAs 2012204399 @default.
• W2012204399 citedByCount "42" @default.
• W2012204399 countsByYear W20122043992012 @default.
• W2012204399 countsByYear W20122043992013 @default.
• W2012204399 countsByYear W20122043992014 @default.
• W2012204399 countsByYear W20122043992015 @default.
• W2012204399 countsByYear W20122043992016 @default.
• W2012204399 countsByYear W20122043992017 @default.
• W2012204399 countsByYear W20122043992019 @default.
• W2012204399 countsByYear W20122043992020 @default.
• W2012204399 countsByYear W20122043992021 @default.
• W2012204399 countsByYear W20122043992022 @default.
• W2012204399 crossrefType "journal-article" @default.
• W2012204399 hasAuthorship W2012204399A5037598943 @default.
• W2012204399 hasAuthorship W2012204399A5037740355 @default.
• W2012204399 hasAuthorship W2012204399A5071983807 @default.
• W2012204399 hasAuthorship W2012204399A5090497008 @default.
• W2012204399 hasConcept C104317684 @default.
• W2012204399 hasConcept C134459356 @default.
• W2012204399 hasConcept C136449434 @default.
• W2012204399 hasConcept C142724271 @default.
• W2012204399 hasConcept C203014093 @default.
• W2012204399 hasConcept C25602115 @default.
• W2012204399 hasConcept C2779134260 @default.
• W2012204399 hasConcept C2779341262 @default.
• W2012204399 hasConcept C2779823659 @default.
• W2012204399 hasConcept C2780695269 @default.
• W2012204399 hasConcept C2780942790 @default.
• W2012204399 hasConcept C54355233 @default.
• W2012204399 hasConcept C67636389 @default.

• next