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- W2012204578 abstract "Mycobacteria in the adjuvant used for induction of experimental autoimmune encephalomyelitis (EAE) in guinea pigs can be replaced by synthetic N-acetylmuramyl-l-alanyl-d-isoglutamine. A combination of synthetic encephalitogenic peptides and muramyl dipeptides induces EAE effectively at a dose on the microgram level. In this system, the synthetic heptapeptide, H-Trp-Gly-Ala-Glu-Gly-Gln-Arg-OH, with a sequence identical to those of residues 116 to 122 of the basic protein of human myelin, was the shortest peptide causing EAE. These compounds form a simple system which should be useful in studies on the mechanism of the cell-mediated autoimmune reaction." @default.
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- W2012204578 date "1978-01-01" @default.
- W2012204578 modified "2023-10-16" @default.
- W2012204578 title "Minimum structural requirements for encephalitogen and for adjuvant in the induction of experimental allergic encephalomyelitis" @default.
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- W2012204578 doi "https://doi.org/10.1016/0008-8749(78)90135-1" @default.
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