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• W2012206660 startingPage "738" @default.
• W2012206660 abstract "Hippocampus plays an important role in learning and memory and in spatial navigation. Production of new neurons that are functionally integrated into the hippocampal neuronal network is important for the maintenance of functional plasticity. In adults, production of new neurons in the hippocampus takes place in the subgranular zone (SGZ) of dentate gyrus. Neural progenitor/stem cells go through processes of proliferation, differentiation, migration, and maturation. This process is exquisitely sensitive to oxidative stress, and perturbation in the redox balance in the neurogenic microenvironment can lead to reduced neurogenesis. Cranial irradiation is an effective treatment for primary and secondary brain tumors. However, even low doses of irradiation can lead to persistent elevation of oxidative stress and sustained suppression of hippocampal neurogenesis. Superoxide dismutases (SODs) are major antioxidant enzymes for the removal of superoxide radicals in different subcellular compartments. To identify the subcellular location where reactive oxygen species (ROS) are continuously generated after cranial irradiation, different SOD deficient mice have been used to determine the effects of irradiation on hippocampal neurogenesis. The study results suggest that, regardless of the subcellular location, SOD deficiency leads to a significant reduction in the production of new neurons in the SGZ of hippocampal dentate gyrus. In exchange, the generation of new glial cells was significantly increased. The SOD deficient condition, however, altered the tissue response to irradiation, and SOD deficient mice were able to maintain a similar level of neurogenesis after irradiation while wild type mice showed a significant reduction in the production of new neurons." @default.
• W2012206660 created "2016-06-24" @default.
• W2012206660 creator A5000919272 @default.
• W2012206660 creator A5035862770 @default.
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• W2012206660 date "2012-09-01" @default.
• W2012206660 modified "2023-10-09" @default.
• W2012206660 title "Oxidative stress and adult neurogenesis—Effects of radiation and superoxide dismutase deficiency" @default.
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• W2012206660 doi "https://doi.org/10.1016/j.semcdb.2012.04.003" @default.
• W2012206660 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3410958" @default.
• W2012206660 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22521481" @default.
• W2012206660 hasPublicationYear "2012" @default.
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