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- W2012207829 abstract "A high-performance liquid chromatographic method using ion-pair chromatography on reversed-phase C 18 material was developed. After sample clean-up on XAD columns, mitoxantrone at concentrations below 1 ng/ml in serum and 0.2 ng/ml in urine were measurable with a coefficient of variation of < 9.3% at a wavelength of 658 nm. Four metabolites were separated in urine. The two major metabolites co-chromatographed with the synthesized mono- and dicarboxylic acid derivatives of mitoxantrone. The method allowed the measurement of mitoxantrone and its metabolites in serum up to more than one week and in urine up to four weeks after administration of the drug." @default.
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- W2012207829 date "1985-01-01" @default.
- W2012207829 modified "2023-09-25" @default.
- W2012207829 title "Detection and separation of mitoxantrone and its metabolites in plasma and urine by high-performance liquid chromatography" @default.
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- W2012207829 doi "https://doi.org/10.1016/s0378-4347(00)84494-1" @default.
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