FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012207951> ?p ?o ?g. }

• W2012207951 endingPage "994" @default.
• W2012207951 startingPage "988" @default.
• W2012207951 abstract "Primary cilia regulate limb and axial skeletal formation and hedgehog signaling, but their roles in temporomandibular joint (TMJ) development are unknown. Thus, we created conditional mouse mutants deficient in ciliary transport protein Kif3a in cartilage. In post-natal wild-type mice, primary cilia were occasionally observed on the superior, inferior, or lateral side of condylar cells. Cilia were barely detectable in mutant chondrocytes but were evident in surrounding tissues, attesting to the specificity of chondrocyte Kif3a ablation. Mutant condyles from 3-month-old mice were narrow and flat along their antero-posterior and medio-lateral axes, were often fused with the articular disc, and displayed an irregular bony surface. The polymorphic layer in P15 mutants contained fewer Sox9-expressing chondroprogenitor cells because of reduced mitotic activity, and newly differentiated chondrocytes underwent precocious hypertrophic enlargement accompanied by early activation of Indian hedgehog (Ihh). Interestingly, there was excessive intramembranous ossification along the perichondrium, accompanied by local expression of the hedgehog receptor Patched-1 and up-regulation of Osterix and Collagen I. In summary, Kif3a and primary cilia are required for coordination of chondrocyte maturation, intramembranous bone formation, and chondrogenic condylar growth. Defects in these processes in Kif3a condylar cartilage are likely to reflect abnormal hedgehog signaling topography and dysfunction." @default.
• W2012207951 created "2016-06-24" @default.
• W2012207951 creator A5002445778 @default.
• W2012207951 creator A5004936719 @default.
• W2012207951 creator A5021768513 @default.
• W2012207951 creator A5023049186 @default.
• W2012207951 creator A5031457712 @default.
• W2012207951 creator A5034138402 @default.
• W2012207951 creator A5054347395 @default.
• W2012207951 creator A5072568785 @default.
• W2012207951 date "2011-05-12" @default.
• W2012207951 modified "2023-09-23" @default.
• W2012207951 title "TMJ Development and Growth Require Primary Cilia Function" @default.
• W2012207951 cites W1493393942 @default.
• W2012207951 cites W1964813168 @default.
• W2012207951 cites W1968904141 @default.
• W2012207951 cites W1971060771 @default.
• W2012207951 cites W1979842902 @default.
• W2012207951 cites W1985648712 @default.
• W2012207951 cites W1989498317 @default.
• W2012207951 cites W1993769414 @default.
• W2012207951 cites W1993851741 @default.
• W2012207951 cites W1994883427 @default.
• W2012207951 cites W1997889647 @default.
• W2012207951 cites W2032485009 @default.
• W2012207951 cites W2032709456 @default.
• W2012207951 cites W2041351247 @default.
• W2012207951 cites W2060065170 @default.
• W2012207951 cites W2064383688 @default.
• W2012207951 cites W2074522272 @default.
• W2012207951 cites W2081956644 @default.
• W2012207951 cites W2087293686 @default.
• W2012207951 cites W2092640712 @default.
• W2012207951 cites W2110341920 @default.
• W2012207951 cites W2113831089 @default.
• W2012207951 cites W2119022046 @default.
• W2012207951 cites W2122367477 @default.
• W2012207951 cites W2136508662 @default.
• W2012207951 cites W2149388536 @default.
• W2012207951 cites W2150134228 @default.
• W2012207951 cites W2158899787 @default.
• W2012207951 cites W2168998715 @default.
• W2012207951 cites W2172253586 @default.
• W2012207951 doi "https://doi.org/10.1177/0022034511409407" @default.
• W2012207951 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6728672" @default.
• W2012207951 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21566205" @default.
• W2012207951 hasPublicationYear "2011" @default.
• W2012207951 type Work @default.
• W2012207951 sameAs 2012207951 @default.
• W2012207951 citedByCount "25" @default.
• W2012207951 countsByYear W20122079512012 @default.
• W2012207951 countsByYear W20122079512013 @default.
• W2012207951 countsByYear W20122079512014 @default.
• W2012207951 countsByYear W20122079512015 @default.
• W2012207951 countsByYear W20122079512016 @default.
• W2012207951 countsByYear W20122079512018 @default.
• W2012207951 countsByYear W20122079512019 @default.
• W2012207951 countsByYear W20122079512020 @default.
• W2012207951 countsByYear W20122079512021 @default.
• W2012207951 countsByYear W20122079512022 @default.
• W2012207951 crossrefType "journal-article" @default.
• W2012207951 hasAuthorship W2012207951A5002445778 @default.
• W2012207951 hasAuthorship W2012207951A5004936719 @default.
• W2012207951 hasAuthorship W2012207951A5021768513 @default.
• W2012207951 hasAuthorship W2012207951A5023049186 @default.
• W2012207951 hasAuthorship W2012207951A5031457712 @default.
• W2012207951 hasAuthorship W2012207951A5034138402 @default.
• W2012207951 hasAuthorship W2012207951A5054347395 @default.
• W2012207951 hasAuthorship W2012207951A5072568785 @default.
• W2012207951 hasBestOaLocation W20122079512 @default.
• W2012207951 hasConcept C100094513 @default.
• W2012207951 hasConcept C104317684 @default.
• W2012207951 hasConcept C105702510 @default.
• W2012207951 hasConcept C143065580 @default.
• W2012207951 hasConcept C145837895 @default.
• W2012207951 hasConcept C17938293 @default.
• W2012207951 hasConcept C188945261 @default.
• W2012207951 hasConcept C25515809 @default.
• W2012207951 hasConcept C2776014264 @default.
• W2012207951 hasConcept C2777994357 @default.
• W2012207951 hasConcept C2778539099 @default.
• W2012207951 hasConcept C2780550940 @default.
• W2012207951 hasConcept C2781403057 @default.
• W2012207951 hasConcept C35496256 @default.
• W2012207951 hasConcept C37590093 @default.
• W2012207951 hasConcept C54355233 @default.
• W2012207951 hasConcept C62478195 @default.
• W2012207951 hasConcept C86803240 @default.
• W2012207951 hasConcept C88498014 @default.
• W2012207951 hasConcept C95444343 @default.
• W2012207951 hasConceptScore W2012207951C100094513 @default.
• W2012207951 hasConceptScore W2012207951C104317684 @default.
• W2012207951 hasConceptScore W2012207951C105702510 @default.
• W2012207951 hasConceptScore W2012207951C143065580 @default.
• W2012207951 hasConceptScore W2012207951C145837895 @default.
• W2012207951 hasConceptScore W2012207951C17938293 @default.
• W2012207951 hasConceptScore W2012207951C188945261 @default.
• W2012207951 hasConceptScore W2012207951C25515809 @default.

• next