FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012208226> ?p ?o ?g. }

• W2012208226 endingPage "2377" @default.
• W2012208226 startingPage "2370" @default.
• W2012208226 abstract "Protein kinase B/Akt has been described as a central mediator of antiapoptotic signals in cancer cells. Furthermore, Akt has been shown to affect cell cycle progression and proliferative pathways and to possess a potential function in tumorigenesis and chemoresistance. In this study, we show that the ectopic expression of a constitutively active form of Akt1 (CA-Akt1) results in enhanced chemoresistance of NCI H460 human NSCLC cells towards a panel of chemotherapeutic agents. To understand the molecular alterations leading to impaired chemosensitivity mediated by activated Akt, we analysed various apoptotic pathways, including the activation of p53, caspases 3, 7, 8, and 9, release of cytochrome c from mitochondria, and the expression levels of pro- and antiapoptotic proteins such as Bcl-2, Bcl-xL, Bcl-xs, Bax, or Bfl-1. We observed that expression of CA-Akt did not interfere with single defined apoptotic switches, but modulated the apoptotic threshold of several apoptotic pathways towards increasing the threshold of onset. In particular, we found that CA-Akt-expressing cells displayed increased expression of the antiapoptotic Bcl-2 family member protein Bcl-xl, and a delayed onset of the p53 pathway after treatment with cisplatin or Mitoxantrone. Thus, our data suggest that Akt mediates chemoresistance in NHI H460 cells by interfering with and delaying the onset of various apoptotic pathways. A complete inactivation of apoptotic pathways was observed in none of the molecular alterations investigated. Our data strengthen the role of Akt as a central mediator of cell survival signals and/or chemoresistance and as an attractive target for cancer cell chemosensitisation." @default.
• W2012208226 created "2016-06-24" @default.
• W2012208226 creator A5040390294 @default.
• W2012208226 creator A5041877900 @default.
• W2012208226 creator A5087890782 @default.
• W2012208226 date "2004-05-11" @default.
• W2012208226 modified "2023-10-12" @default.
• W2012208226 title "Molecular alterations in apoptotic pathways after PKB/Akt-mediated chemoresistance in NCI H460 cells" @default.
• W2012208226 cites W1506642042 @default.
• W2012208226 cites W1509669696 @default.
• W2012208226 cites W1564408770 @default.
• W2012208226 cites W1607892649 @default.
• W2012208226 cites W1617532721 @default.
• W2012208226 cites W1970548320 @default.
• W2012208226 cites W1971967721 @default.
• W2012208226 cites W1975290731 @default.
• W2012208226 cites W1985999867 @default.
• W2012208226 cites W1986785675 @default.
• W2012208226 cites W1991300200 @default.
• W2012208226 cites W1996695017 @default.
• W2012208226 cites W1996982933 @default.
• W2012208226 cites W1997006452 @default.
• W2012208226 cites W1998038367 @default.
• W2012208226 cites W2024306318 @default.
• W2012208226 cites W2026228428 @default.
• W2012208226 cites W2026389696 @default.
• W2012208226 cites W2028268047 @default.
• W2012208226 cites W2040988759 @default.
• W2012208226 cites W2044825593 @default.
• W2012208226 cites W2045201777 @default.
• W2012208226 cites W2058138221 @default.
• W2012208226 cites W2059221693 @default.
• W2012208226 cites W2061105502 @default.
• W2012208226 cites W2063013228 @default.
• W2012208226 cites W2065919583 @default.
• W2012208226 cites W2068912983 @default.
• W2012208226 cites W2069508460 @default.
• W2012208226 cites W2071475119 @default.
• W2012208226 cites W2079605745 @default.
• W2012208226 cites W2094123695 @default.
• W2012208226 cites W2096286606 @default.
• W2012208226 cites W2097767970 @default.
• W2012208226 cites W2106770132 @default.
• W2012208226 cites W2111101616 @default.
• W2012208226 cites W2112902082 @default.
• W2012208226 cites W2123408027 @default.
• W2012208226 cites W2123619341 @default.
• W2012208226 cites W2137035181 @default.
• W2012208226 cites W2139333680 @default.
• W2012208226 cites W2156319255 @default.
• W2012208226 cites W2157158866 @default.
• W2012208226 cites W2414261930 @default.
• W2012208226 cites W2467229516 @default.
• W2012208226 doi "https://doi.org/10.1038/sj.bjc.6601876" @default.
• W2012208226 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2409515" @default.
• W2012208226 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15150572" @default.
• W2012208226 hasPublicationYear "2004" @default.
• W2012208226 type Work @default.
• W2012208226 sameAs 2012208226 @default.
• W2012208226 citedByCount "51" @default.
• W2012208226 countsByYear W20122082262013 @default.
• W2012208226 countsByYear W20122082262014 @default.
• W2012208226 countsByYear W20122082262015 @default.
• W2012208226 countsByYear W20122082262016 @default.
• W2012208226 countsByYear W20122082262019 @default.
• W2012208226 countsByYear W20122082262020 @default.
• W2012208226 countsByYear W20122082262021 @default.
• W2012208226 countsByYear W20122082262022 @default.
• W2012208226 countsByYear W20122082262023 @default.
• W2012208226 crossrefType "journal-article" @default.
• W2012208226 hasAuthorship W2012208226A5040390294 @default.
• W2012208226 hasAuthorship W2012208226A5041877900 @default.
• W2012208226 hasAuthorship W2012208226A5087890782 @default.
• W2012208226 hasBestOaLocation W20122082261 @default.
• W2012208226 hasConcept C121608353 @default.
• W2012208226 hasConcept C154137905 @default.
• W2012208226 hasConcept C163421366 @default.
• W2012208226 hasConcept C190283241 @default.
• W2012208226 hasConcept C29311851 @default.
• W2012208226 hasConcept C29537977 @default.
• W2012208226 hasConcept C31573885 @default.
• W2012208226 hasConcept C502942594 @default.
• W2012208226 hasConcept C54355233 @default.
• W2012208226 hasConcept C55493867 @default.
• W2012208226 hasConcept C555283112 @default.
• W2012208226 hasConcept C62478195 @default.
• W2012208226 hasConcept C75217442 @default.
• W2012208226 hasConcept C81885089 @default.
• W2012208226 hasConcept C86803240 @default.
• W2012208226 hasConcept C95444343 @default.
• W2012208226 hasConcept C97037327 @default.
• W2012208226 hasConcept C98424977 @default.
• W2012208226 hasConceptScore W2012208226C121608353 @default.
• W2012208226 hasConceptScore W2012208226C154137905 @default.
• W2012208226 hasConceptScore W2012208226C163421366 @default.
• W2012208226 hasConceptScore W2012208226C190283241 @default.
• W2012208226 hasConceptScore W2012208226C29311851 @default.
• W2012208226 hasConceptScore W2012208226C29537977 @default.

• next