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• W201220858 abstract "HA is an extremely large molecule (normally 1-5 million daltons) of repeating subunits of Nacetylglucosamine and glucuronate (1-14). HA is classified as a glycosaminoglycan (GAG), and is present physiologically and commercially as the sodium salt (sodium hyaluronate). Single HA molecules exist as a hydrophilic, coiled mass approximately 200 nm in diameter, but form a mesh under typical in vivo conditions (8). HA is found everywhere in the body, but has especially important roles in joints. HA is the primary agent responsible for the viscosity and lubricating properties of synovial fluid (6, 8, 11-29). In cartilage, HA serves as the backbone of aggrecan proteoglycans, bound to core and link proteins (18, 30-49). Furthermore, HA is an important and under-recognized regulator of cell and tissue functions, as shown by the presence of specific receptors on all cells for HA and its fragments (8, 11-14, 50-65). The scientific and medical literature on HA and its effects on joints has had virtually no references to oral use of HA until very recently. Instead, HA has a prodigious literature on biological effects (6, 8, 11-14, 19-26, 28, 62, 66, 67), including a rather large number of in vivo animal and human clinical studies using intraarticular injections to treat osteoarthritis (OA) with purified HA (reviewed in 21, 22, 25, 26, 68-86). Thus, there is substantial knowledge of the biological effects of purified, high molecular weight HA on joint health." @default.
• W201220858 created "2016-06-24" @default.
• W201220858 creator A5065063629 @default.
• W201220858 date "2006-01-01" @default.
• W201220858 modified "2023-09-24" @default.
• W201220858 title "WILL THE REAL HYALURONAN PLEASE STAND UP" @default.
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