FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012209901> ?p ?o ?g. }

• W2012209901 endingPage "484" @default.
• W2012209901 startingPage "477" @default.
• W2012209901 abstract "Hypoxanthine (HPX) uptake was investigated in four human tumour cell lines previously characterised as being sensitive (ds: A549 and MCF7) or insensitive (di: COR-L23 and T-47D) to dipyridamole (DP)-induced inhibition of HPX rescue from antipurine antifolate-induced growth inhibition. The aim of the study was to determine the mechanism underlying the differential sensitivity of HPX rescue to DP. The time-course of HPX uptake in the two ds cell lines was different in comparison to the two di cell lines. The initial rate of HPX uptake in the di cell lines was more rapid than in the ds cell lines such that at 60 sec the amount of HPX taken up by the former was 2-6 times higher than that taken up by the later. The K(t) and T(max) for HPX transport in di COR-L23 cells were 870 microM and 4.75 microM/10(6) cells/min and 1390 microM and 1.78 microM/10(6) cells/min in ds A549 cells. HPX transport was not sodium-dependent in these cells. Equilibrative nucleoside transporter 2 (ENT2)-mediated thymidine transport was also higher in di cells. DP inhibited HPX uptake into ds cell lines by > or =48% and by < or =20% in the di cell lines. Competition studies with HPX and thymidine transport via ENT2 indicated an overlap between nucleoside and nucleobase transport transporters in the breast cancer cell lines (MCF7 and T-47D). These studies showed that more rapid and extensive HPX uptake, as well as reduced sensitivity to DP inhibition, is associated with the inability of DP to prevent HPX rescue from antipurine antifolate-induced growth inhibition in certain human tumour cell lines." @default.
• W2012209901 created "2016-06-24" @default.
• W2012209901 creator A5032387920 @default.
• W2012209901 creator A5037369531 @default.
• W2012209901 creator A5037630007 @default.
• W2012209901 creator A5037778274 @default.
• W2012209901 creator A5055343915 @default.
• W2012209901 date "2001-02-01" @default.
• W2012209901 modified "2023-10-14" @default.
• W2012209901 title "Hypoxanthine transport in human tumour cell lines. Relationship to the inhibition of hypoxanthine rescue by dipyridamole22Abbreviations: ENT, equilibrative nucleoside transporter; CNT, concentrative nucleoside transporter; DP, dipyridamole; HPX, hypoxanthine; NBTI, nitrobenzylthioinosine; TdR, thymidine; Kt, kinetic constant for tansport; and Tmax, maximum velocity for transport." @default.
• W2012209901 cites W1510642356 @default.
• W2012209901 cites W1538643202 @default.
• W2012209901 cites W1580759730 @default.
• W2012209901 cites W1591471179 @default.
• W2012209901 cites W1687021633 @default.
• W2012209901 cites W1831079403 @default.
• W2012209901 cites W1869455905 @default.
• W2012209901 cites W1967675162 @default.
• W2012209901 cites W1969125109 @default.
• W2012209901 cites W1976365732 @default.
• W2012209901 cites W1976764536 @default.
• W2012209901 cites W1978667402 @default.
• W2012209901 cites W1980003414 @default.
• W2012209901 cites W1981040381 @default.
• W2012209901 cites W2011101951 @default.
• W2012209901 cites W2055499537 @default.
• W2012209901 cites W2060876849 @default.
• W2012209901 cites W2061147784 @default.
• W2012209901 cites W2083313025 @default.
• W2012209901 cites W2083538757 @default.
• W2012209901 cites W2093276314 @default.
• W2012209901 cites W2093790579 @default.
• W2012209901 cites W2343100729 @default.
• W2012209901 cites W2418496934 @default.
• W2012209901 doi "https://doi.org/10.1016/s0006-2952(00)00574-8" @default.
• W2012209901 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11226382" @default.
• W2012209901 hasPublicationYear "2001" @default.
• W2012209901 type Work @default.
• W2012209901 sameAs 2012209901 @default.
• W2012209901 citedByCount "8" @default.
• W2012209901 countsByYear W20122099012013 @default.
• W2012209901 countsByYear W20122099012014 @default.
• W2012209901 countsByYear W20122099012015 @default.
• W2012209901 countsByYear W20122099012017 @default.
• W2012209901 crossrefType "journal-article" @default.
• W2012209901 hasAuthorship W2012209901A5032387920 @default.
• W2012209901 hasAuthorship W2012209901A5037369531 @default.
• W2012209901 hasAuthorship W2012209901A5037630007 @default.
• W2012209901 hasAuthorship W2012209901A5037778274 @default.
• W2012209901 hasAuthorship W2012209901A5055343915 @default.
• W2012209901 hasConcept C104317684 @default.
• W2012209901 hasConcept C149011108 @default.
• W2012209901 hasConcept C153911025 @default.
• W2012209901 hasConcept C181199279 @default.
• W2012209901 hasConcept C185592680 @default.
• W2012209901 hasConcept C202751555 @default.
• W2012209901 hasConcept C2776543447 @default.
• W2012209901 hasConcept C2776991684 @default.
• W2012209901 hasConcept C2777108182 @default.
• W2012209901 hasConcept C2780549722 @default.
• W2012209901 hasConcept C2781116151 @default.
• W2012209901 hasConcept C54355233 @default.
• W2012209901 hasConcept C55493867 @default.
• W2012209901 hasConcept C81885089 @default.
• W2012209901 hasConcept C86803240 @default.
• W2012209901 hasConceptScore W2012209901C104317684 @default.
• W2012209901 hasConceptScore W2012209901C149011108 @default.
• W2012209901 hasConceptScore W2012209901C153911025 @default.
• W2012209901 hasConceptScore W2012209901C181199279 @default.
• W2012209901 hasConceptScore W2012209901C185592680 @default.
• W2012209901 hasConceptScore W2012209901C202751555 @default.
• W2012209901 hasConceptScore W2012209901C2776543447 @default.
• W2012209901 hasConceptScore W2012209901C2776991684 @default.
• W2012209901 hasConceptScore W2012209901C2777108182 @default.
• W2012209901 hasConceptScore W2012209901C2780549722 @default.
• W2012209901 hasConceptScore W2012209901C2781116151 @default.
• W2012209901 hasConceptScore W2012209901C54355233 @default.
• W2012209901 hasConceptScore W2012209901C55493867 @default.
• W2012209901 hasConceptScore W2012209901C81885089 @default.
• W2012209901 hasConceptScore W2012209901C86803240 @default.
• W2012209901 hasIssue "4" @default.
• W2012209901 hasLocation W20122099011 @default.
• W2012209901 hasLocation W20122099012 @default.
• W2012209901 hasOpenAccess W2012209901 @default.
• W2012209901 hasPrimaryLocation W20122099011 @default.
• W2012209901 hasRelatedWork W1973335819 @default.
• W2012209901 hasRelatedWork W1979609612 @default.
• W2012209901 hasRelatedWork W2012209901 @default.
• W2012209901 hasRelatedWork W2028198387 @default.
• W2012209901 hasRelatedWork W2031608471 @default.
• W2012209901 hasRelatedWork W2047659261 @default.
• W2012209901 hasRelatedWork W2066376934 @default.
• W2012209901 hasRelatedWork W2094823575 @default.
• W2012209901 hasRelatedWork W2207759164 @default.
• W2012209901 hasRelatedWork W4237192508 @default.
• W2012209901 hasVolume "61" @default.
• W2012209901 isParatext "false" @default.
• W2012209901 isRetracted "false" @default.

• next