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- W2012220802 abstract "Studies in my lab have focused on DNA transposition in the bacterial virus, Mu. In vitro studies have shown that Mu DNA transposition is a three-step process involving DNA breakage, strand transfer and DNA replication. In the first step, a nick is introduced at each end of the transposon. The liberated 3'-OH groups subsequently attack a target DNA molecule resulting in strand transfer. The transposon DNA, now covalently linked to the target, is finally replicated to generate the transposition end-product, referred to as a cointegrate. The DNA cleavage and strand transfer reactions are mediated by a jumping gene machine or transpososomes, which we discovered in 1987. They are assembled by bringing together three different DNA regions via a process involving multiple protein-DNA and protein-protein interactions. The action of four different proteins is required in addition to protein-induced DNA bending or wrapping to overcome the intrinsic stiffness of DNA, which would ordinarily prohibit the assembly of such a structure. Transpososome assembly is a gradual process involving multiple steps with an inherent flexibility whereby alternate pathways can be used in the assembly process, biasing the reaction towards completion under different conditions.Key words: DNA transposition, transposons, higher-order nucleoprotein complexes, DNA breakage and reunion, site-specific recombination." @default.
- W2012220802 created "2016-06-24" @default.
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- W2012220802 date "1999-12-01" @default.
- W2012220802 modified "2023-09-27" @default.
- W2012220802 title "1999 Roche Diagnostics Prize for Biomolecular and Cellular Research / Prix Roche Diagnostics 1999 pour la recherche en biologie moléculaire et cellulaireStudies on a jumping gene machine: Higher-order nucleoprotein complexes in Mu DNA transposition" @default.
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- W2012220802 doi "https://doi.org/10.1139/o99-060" @default.
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