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- W2012243722 abstract "Radioactive cyanide injected into the dog appears in the “free” cyanide, vitamin B12-bound cyanide, and the thiocyanate of the urine. Data are presented which indicate that the cyano group of vitamin B12 is rapidly taking up injected cyanide and that the vitamin B12 comes into equilibrium with a small metabolically active pool of cyanide. Cyanide and thiocyanate are in a dynamic equilibrium as demonstrated by the specific activity of hydrogen cyanide exhaled by rats after injection of radioactive cyanide and of radioactive thiocyanate. Cyanide as well as thiocyanate carbon is converted to carbon dioxide in the rat. The carbon of thiocyanate has a biological half life of 3.6 days and is replaced at a rate of 19% per day in the rat. About two-thirds of the thiocyanate carbon replaced are excreted as thiocyanate in the urine and one third as carbon dioxide in the respiratory air. Cyanide carbon, and therefore by metabolic equilibrium thiocyanate carbon, appears in the methyl carbons of choline and methionine, and in the ureide carbons of allantoin. The specific activity of the isolated formate makes it a very probable intermediate for this conversion. Relatively high activity has been observed in the carbon of liver proteins, and possible interpretations are discussed. The liver fatty acids show a low order of activity which is probably derived from carbon dioxide. Evidence is presented that to a large extent cyanide and thiocyanate carbon are oxidized directly to carbon dioxide, possibly via cyanate." @default.
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- W2012243722 date "1952-07-01" @default.
- W2012243722 modified "2023-09-27" @default.
- W2012243722 title "Studies on the metabolism of the carbon of cyanide and thiocyanate" @default.
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- W2012243722 doi "https://doi.org/10.1016/0003-9861(52)90256-7" @default.
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