FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012244168> ?p ?o ?g. }

• W2012244168 endingPage "e21674" @default.
• W2012244168 startingPage "e21674" @default.
• W2012244168 abstract "The active vitamin D metabolite, 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), has been shown to be an important regulator of innate and adaptive immune function. In addition, synthesis of 1,25(OH)(2)D(3) from 25-hydroxyvitamin D(3) (25(OH)D(3)) by the enzyme 1α-hydroxylase in monocytes upon activation by TLR signaling has been found to regulate innate immune responses of monocytes in an intracrine fashion. In this study we wanted to determine what cells expressed 1α-hydroxylase in stimulated peripheral blood mononuclear cell (PBMC) cultures and if conversion of 25(OH)D(3) to 1,25(OH)(2)D(3) in PBMC cultures regulated antigen-specific immune responses. Initially, we found that stimulation of PBMCs from animals vaccinated with Mycobacterium bovis (M. bovis) BCG with purified protein derivative of M. bovis (M. bovis PPD) induced 1α-hydroxylase gene expression and that treatment with a physiological concentration of 25(OH)D(3) down-regulated IFN-γ and IL-17F gene expression. Next, we stimulated PBMCs from M. bovis BCG-vaccinated and non-vaccinated cattle with M. bovis PPD and sorted them by FACS according to surface markers for monocytes/macrophages (CD14), B cells (IgM), and T cells (CD3). Sorting the PBMCs revealed that 1α-hydroxylase expression was induced in the monocytes and B cells, but not in the T cells. Furthermore, treatment of stimulated PBMCs with 25(OH)D(3) down-regulated antigen-specific IFN-γ and IL-17F responses in the T cells, even though 1α-hydroxylase expression was not induced in the T cells. Based on evidence of no T cell 1α-hydroxylase we hypothesize that activated monocytes and B cells synthesize 1,25(OH)(2)D(3) and that 1,25(OH)(2)D(3) down-regulates antigen-specific expression of IFN-γ and IL-17F in T cells in a paracrine fashion." @default.
• W2012244168 created "2016-06-24" @default.
• W2012244168 creator A5023408977 @default.
• W2012244168 creator A5035572850 @default.
• W2012244168 creator A5062843024 @default.
• W2012244168 creator A5074565889 @default.
• W2012244168 creator A5076034149 @default.
• W2012244168 creator A5089248847 @default.
• W2012244168 date "2011-06-28" @default.
• W2012244168 modified "2023-09-26" @default.
• W2012244168 title "Regulation of Mycobacterium-Specific Mononuclear Cell Responses by 25-Hydroxyvitamin D3" @default.
• W2012244168 cites W139833353 @default.
• W2012244168 cites W1544385648 @default.
• W2012244168 cites W1551028857 @default.
• W2012244168 cites W1620799781 @default.
• W2012244168 cites W1797064712 @default.
• W2012244168 cites W1866685620 @default.
• W2012244168 cites W1959947954 @default.
• W2012244168 cites W1968381959 @default.
• W2012244168 cites W1968870913 @default.
• W2012244168 cites W1972181361 @default.
• W2012244168 cites W1975876211 @default.
• W2012244168 cites W1979139141 @default.
• W2012244168 cites W1993349407 @default.
• W2012244168 cites W1993447020 @default.
• W2012244168 cites W2006083207 @default.
• W2012244168 cites W2006602207 @default.
• W2012244168 cites W2007223760 @default.
• W2012244168 cites W2007331929 @default.
• W2012244168 cites W2012963050 @default.
• W2012244168 cites W2013248652 @default.
• W2012244168 cites W2013607572 @default.
• W2012244168 cites W2014444933 @default.
• W2012244168 cites W2016323086 @default.
• W2012244168 cites W2024861702 @default.
• W2012244168 cites W2025602245 @default.
• W2012244168 cites W2028787451 @default.
• W2012244168 cites W2037299986 @default.
• W2012244168 cites W2039709829 @default.
• W2012244168 cites W2044645610 @default.
• W2012244168 cites W2045218246 @default.
• W2012244168 cites W2045277420 @default.
• W2012244168 cites W2050954609 @default.
• W2012244168 cites W2052337638 @default.
• W2012244168 cites W2052432144 @default.
• W2012244168 cites W2052505493 @default.
• W2012244168 cites W2055001990 @default.
• W2012244168 cites W2056247628 @default.
• W2012244168 cites W2057735692 @default.
• W2012244168 cites W2064150291 @default.
• W2012244168 cites W2065544998 @default.
• W2012244168 cites W2084638542 @default.
• W2012244168 cites W2087705083 @default.
• W2012244168 cites W2088933994 @default.
• W2012244168 cites W2089533451 @default.
• W2012244168 cites W2097684744 @default.
• W2012244168 cites W2099432378 @default.
• W2012244168 cites W2103024679 @default.
• W2012244168 cites W2106185842 @default.
• W2012244168 cites W2106449126 @default.
• W2012244168 cites W2107277218 @default.
• W2012244168 cites W2107905356 @default.
• W2012244168 cites W2110730271 @default.
• W2012244168 cites W2113799034 @default.
• W2012244168 cites W2116520267 @default.
• W2012244168 cites W2124580054 @default.
• W2012244168 cites W2125146117 @default.
• W2012244168 cites W2126574528 @default.
• W2012244168 cites W2126617070 @default.
• W2012244168 cites W2133378877 @default.
• W2012244168 cites W2135604027 @default.
• W2012244168 cites W2143565640 @default.
• W2012244168 cites W2144766427 @default.
• W2012244168 cites W2148646748 @default.
• W2012244168 cites W2150990505 @default.
• W2012244168 cites W2155875835 @default.
• W2012244168 cites W2156503894 @default.
• W2012244168 cites W2161645061 @default.
• W2012244168 cites W2164176723 @default.
• W2012244168 cites W2170814415 @default.
• W2012244168 cites W2469287579 @default.
• W2012244168 doi "https://doi.org/10.1371/journal.pone.0021674" @default.
• W2012244168 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3125300" @default.
• W2012244168 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21738762" @default.
• W2012244168 hasPublicationYear "2011" @default.
• W2012244168 type Work @default.
• W2012244168 sameAs 2012244168 @default.
• W2012244168 citedByCount "37" @default.
• W2012244168 countsByYear W20122441682012 @default.
• W2012244168 countsByYear W20122441682013 @default.
• W2012244168 countsByYear W20122441682014 @default.
• W2012244168 countsByYear W20122441682015 @default.
• W2012244168 countsByYear W20122441682016 @default.
• W2012244168 countsByYear W20122441682017 @default.
• W2012244168 countsByYear W20122441682018 @default.
• W2012244168 countsByYear W20122441682019 @default.
• W2012244168 countsByYear W20122441682020 @default.
• W2012244168 countsByYear W20122441682021 @default.

• next