FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012244178> ?p ?o ?g. }

• W2012244178 endingPage "218" @default.
• W2012244178 startingPage "210" @default.
• W2012244178 abstract "Knowledge of specific neurotransmitters as well as the pathways and mechanisms regulating appetite in ruminants that continually graze, such as sheep, is incomplete. Although fundamentally agouti-related protein (AGRP) has a similar function across species to increase food intake, the regulation of AGRP may vary across grazing and intermittent feeders. To investigate the role of orexigenic peptides in the regulation of feed intake, we first extracted messenger RNA from sheep that were fasted for 3 days, which was then used for PCR followed by cloning and sequencing to demonstrate the presence of hypothalamic AGRP expression. Ovine AGRP was closely related to the bovine, but contained sequence differences with human and mouse AGRP. Analysis of genomic DNA also revealed a similar gene structure to other published species. Secondly, using dual-labeled immunohistochemistry, we determined that there was both increased AGRP immunoreactivity and increased abundance of c-Fos immunoreactivity in AGRP neurons in the arcuate nucleus of fasted sheep. Because AGRP neurons are activated by fasting, we hypothesized that AGRP would stimulate feeding in this ruminant species. Sheep fed ad libitum were injected intracerebroventricularly with concentrations of AGRP at 0.2 and 2.0 nmol/kg. AGRP at 2.0 nmol/kg significantly increased food intake at 4, 6 and 12 h (p < 0.05). A 4th study was done to investigate the interactions of AGRP and neuropeptide Y (NPY) on food intake over a 24-hour period. Intracerebroventricular injections of either AGRP or NPY significantly increased cumulative food intake over saline controls. When AGRP and NPY were injected in combination, food intake was increased over saline controls; however, AGRP did not potentiate the effects of NPY. These results demonstrate that AGRP stimulates food intake in sheep and highlights the important differences between this species and rodent models." @default.
• W2012244178 created "2016-06-24" @default.
• W2012244178 creator A5000850327 @default.
• W2012244178 creator A5004405622 @default.
• W2012244178 creator A5013598761 @default.
• W2012244178 creator A5033696044 @default.
• W2012244178 creator A5038447639 @default.
• W2012244178 creator A5061490894 @default.
• W2012244178 date "2004-01-01" @default.
• W2012244178 modified "2023-10-13" @default.
• W2012244178 title "A Role for Agouti-Related Protein in Appetite Regulation in a Species with Continuous Nutrient Delivery" @default.
• W2012244178 cites W116395403 @default.
• W2012244178 cites W1498073324 @default.
• W2012244178 cites W1499189927 @default.
• W2012244178 cites W1555861401 @default.
• W2012244178 cites W1698695320 @default.
• W2012244178 cites W1965616431 @default.
• W2012244178 cites W1977182289 @default.
• W2012244178 cites W1978089427 @default.
• W2012244178 cites W1979047029 @default.
• W2012244178 cites W1982514291 @default.
• W2012244178 cites W1998422932 @default.
• W2012244178 cites W2012731077 @default.
• W2012244178 cites W2020270875 @default.
• W2012244178 cites W2022246439 @default.
• W2012244178 cites W2040180159 @default.
• W2012244178 cites W2047386718 @default.
• W2012244178 cites W2053421794 @default.
• W2012244178 cites W2056736131 @default.
• W2012244178 cites W2057063716 @default.
• W2012244178 cites W2065389660 @default.
• W2012244178 cites W2095351701 @default.
• W2012244178 cites W2098741413 @default.
• W2012244178 cites W2164354775 @default.
• W2012244178 cites W4231314870 @default.
• W2012244178 cites W4242457804 @default.
• W2012244178 cites W4246310719 @default.
• W2012244178 doi "https://doi.org/10.1159/000082735" @default.
• W2012244178 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15604600" @default.
• W2012244178 hasPublicationYear "2004" @default.
• W2012244178 type Work @default.
• W2012244178 sameAs 2012244178 @default.
• W2012244178 citedByCount "39" @default.
• W2012244178 countsByYear W20122441782012 @default.
• W2012244178 countsByYear W20122441782013 @default.
• W2012244178 countsByYear W20122441782014 @default.
• W2012244178 countsByYear W20122441782015 @default.
• W2012244178 countsByYear W20122441782016 @default.
• W2012244178 countsByYear W20122441782017 @default.
• W2012244178 countsByYear W20122441782020 @default.
• W2012244178 countsByYear W20122441782021 @default.
• W2012244178 countsByYear W20122441782022 @default.
• W2012244178 crossrefType "journal-article" @default.
• W2012244178 hasAuthorship W2012244178A5000850327 @default.
• W2012244178 hasAuthorship W2012244178A5004405622 @default.
• W2012244178 hasAuthorship W2012244178A5013598761 @default.
• W2012244178 hasAuthorship W2012244178A5033696044 @default.
• W2012244178 hasAuthorship W2012244178A5038447639 @default.
• W2012244178 hasAuthorship W2012244178A5061490894 @default.
• W2012244178 hasConcept C118303440 @default.
• W2012244178 hasConcept C126322002 @default.
• W2012244178 hasConcept C134018914 @default.
• W2012244178 hasConcept C170493617 @default.
• W2012244178 hasConcept C2777003273 @default.
• W2012244178 hasConcept C2777205416 @default.
• W2012244178 hasConcept C2778458369 @default.
• W2012244178 hasConcept C3018685816 @default.
• W2012244178 hasConcept C71924100 @default.
• W2012244178 hasConcept C75908981 @default.
• W2012244178 hasConcept C86803240 @default.
• W2012244178 hasConcept C93984277 @default.
• W2012244178 hasConceptScore W2012244178C118303440 @default.
• W2012244178 hasConceptScore W2012244178C126322002 @default.
• W2012244178 hasConceptScore W2012244178C134018914 @default.
• W2012244178 hasConceptScore W2012244178C170493617 @default.
• W2012244178 hasConceptScore W2012244178C2777003273 @default.
• W2012244178 hasConceptScore W2012244178C2777205416 @default.
• W2012244178 hasConceptScore W2012244178C2778458369 @default.
• W2012244178 hasConceptScore W2012244178C3018685816 @default.
• W2012244178 hasConceptScore W2012244178C71924100 @default.
• W2012244178 hasConceptScore W2012244178C75908981 @default.
• W2012244178 hasConceptScore W2012244178C86803240 @default.
• W2012244178 hasConceptScore W2012244178C93984277 @default.
• W2012244178 hasIssue "4" @default.
• W2012244178 hasLocation W20122441781 @default.
• W2012244178 hasLocation W20122441782 @default.
• W2012244178 hasOpenAccess W2012244178 @default.
• W2012244178 hasPrimaryLocation W20122441781 @default.
• W2012244178 hasRelatedWork W138388401 @default.
• W2012244178 hasRelatedWork W1909149883 @default.
• W2012244178 hasRelatedWork W1964237829 @default.
• W2012244178 hasRelatedWork W2012302211 @default.
• W2012244178 hasRelatedWork W2054802001 @default.
• W2012244178 hasRelatedWork W2083613579 @default.
• W2012244178 hasRelatedWork W2089791460 @default.
• W2012244178 hasRelatedWork W2883419112 @default.
• W2012244178 hasRelatedWork W44379296 @default.
• W2012244178 hasRelatedWork W2186431338 @default.

• next