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- W2012244194 startingPage "681" @default.
- W2012244194 abstract "Left ventricular hypertrophy (LVH), despite its adaptive nature, is associated with an increased risk of cardiovascular morbidity and mortality. Achievement of LVH regression is thus considered a principal therapeutic aim. However, regression of LVH induced by various therapeutic means may exhibit differing patterns, with variable biological implications. Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase (statins) have been shown to induce prevention or regression of LVH in different models of pathological myocardial growth. In addition to reduction of LV mass, statins were shown to reduce myocardial fibrosis, increase capillary density network and attenuate electrical instability of the hypertrophied heart. Most importantly, statins improved systolic and diastolic LV function and even decreased mortality. The inhibition of hypertrophic growth was only partly achieved by reduction of haemodynamic overload. Direct mechanisms, such as inhibition of neurohumoral activation in the myocardial tissue, attenuated production of growth factors and markers of inflammation and reduction of oxidative stress also seem to participate. The protective effect of statins was associated with the inhibition of expression and activation of small guanosintriphosphate-binding proteins such as Ras and Rho, which control the intensity of oxidative stress, the production and availability of nitric oxide, and the expression of genes involved in myocardial growth. In addition to reduction of LV mass, statins may also improve the prognosis of LVH independently of their lipid-lowering effect." @default.
- W2012244194 created "2016-06-24" @default.
- W2012244194 creator A5000931943 @default.
- W2012244194 date "2007-07-31" @default.
- W2012244194 modified "2023-10-15" @default.
- W2012244194 title "Statins: a perspective for left ventricular hypertrophy treatment" @default.
- W2012244194 cites W137106639 @default.
- W2012244194 cites W1582802379 @default.
- W2012244194 cites W1769893219 @default.
- W2012244194 cites W178224015 @default.
- W2012244194 cites W1967615630 @default.
- W2012244194 cites W1967643462 @default.
- W2012244194 cites W1969643800 @default.
- W2012244194 cites W1972952557 @default.
- W2012244194 cites W1976791051 @default.
- W2012244194 cites W1977152294 @default.
- W2012244194 cites W1979900124 @default.
- W2012244194 cites W1981485503 @default.
- W2012244194 cites W1983069625 @default.
- W2012244194 cites W1983692570 @default.
- W2012244194 cites W1986508379 @default.
- W2012244194 cites W1989155094 @default.
- W2012244194 cites W1989375528 @default.
- W2012244194 cites W1989466877 @default.
- W2012244194 cites W1993380848 @default.
- W2012244194 cites W1994547485 @default.
- W2012244194 cites W1995217795 @default.
- W2012244194 cites W1995956780 @default.
- W2012244194 cites W1997172880 @default.
- W2012244194 cites W1997692952 @default.
- W2012244194 cites W2000088166 @default.
- W2012244194 cites W2003980493 @default.
- W2012244194 cites W2005995626 @default.
- W2012244194 cites W2009550262 @default.
- W2012244194 cites W2010961721 @default.
- W2012244194 cites W2014355830 @default.
- W2012244194 cites W2019380461 @default.
- W2012244194 cites W2024782147 @default.
- W2012244194 cites W2029015503 @default.
- W2012244194 cites W2030958629 @default.
- W2012244194 cites W2031185570 @default.
- W2012244194 cites W2031203524 @default.
- W2012244194 cites W2031313044 @default.
- W2012244194 cites W2033404807 @default.
- W2012244194 cites W2033939793 @default.
- W2012244194 cites W2033982272 @default.
- W2012244194 cites W2035132582 @default.
- W2012244194 cites W2035141912 @default.
- W2012244194 cites W2035218356 @default.
- W2012244194 cites W2036061790 @default.
- W2012244194 cites W2038552797 @default.
- W2012244194 cites W2040025337 @default.
- W2012244194 cites W2044045435 @default.
- W2012244194 cites W2045892052 @default.
- W2012244194 cites W2049343064 @default.
- W2012244194 cites W2050822891 @default.
- W2012244194 cites W2051156577 @default.
- W2012244194 cites W2051441972 @default.
- W2012244194 cites W2051560454 @default.
- W2012244194 cites W2051587975 @default.
- W2012244194 cites W2051640426 @default.
- W2012244194 cites W2053816472 @default.
- W2012244194 cites W2060974847 @default.
- W2012244194 cites W2061030879 @default.
- W2012244194 cites W2062512434 @default.
- W2012244194 cites W2062801043 @default.
- W2012244194 cites W2064001901 @default.
- W2012244194 cites W2064024971 @default.
- W2012244194 cites W2064533570 @default.
- W2012244194 cites W2066996797 @default.
- W2012244194 cites W2083638765 @default.
- W2012244194 cites W2087910837 @default.
- W2012244194 cites W2088451948 @default.
- W2012244194 cites W2092242759 @default.
- W2012244194 cites W2092862959 @default.
- W2012244194 cites W2094683943 @default.
- W2012244194 cites W2095944884 @default.
- W2012244194 cites W2097061882 @default.
- W2012244194 cites W2097595842 @default.
- W2012244194 cites W2099309899 @default.
- W2012244194 cites W2102403468 @default.
- W2012244194 cites W2102858052 @default.
- W2012244194 cites W2103429005 @default.
- W2012244194 cites W2106227706 @default.
- W2012244194 cites W2112403981 @default.
- W2012244194 cites W2113656874 @default.
- W2012244194 cites W2114328488 @default.
- W2012244194 cites W2114696344 @default.
- W2012244194 cites W2115693238 @default.
- W2012244194 cites W2115826870 @default.
- W2012244194 cites W2120194464 @default.
- W2012244194 cites W2122036564 @default.
- W2012244194 cites W2122202708 @default.
- W2012244194 cites W2124822093 @default.
- W2012244194 cites W2129750583 @default.
- W2012244194 cites W2130760108 @default.
- W2012244194 cites W2133012200 @default.
- W2012244194 cites W2133217116 @default.