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- W2012245639 abstract "Measurements of extracellular Ca2+ and K+ activities ([Ca2+]0, [K+]0) in the superfused cat carotid body in vitro with triple-barrelled ion-selective electrodes have shown that hypoxia induced a decrease in [Ca2+]0, of0.035 ± 0.17mM(mean±S.D.; n = 17 and biphasic change in [K+]0 which consisted of an increase of2.3 ± 1.8mM followed by an undershoot of−0.52 ± 0.34mM(mean±S.D.;n = 17). Hypercapnia induced a monophasic upward deflection increase of both [Ca2+]0 and [K+]0 of about0.037 ± 0.013mM0.33 ± 0.15mM, respectively (n = 17. During hypoxia, lowering [Ca2+] in the medium to 0.1 mM resulted in a reversed [Ca2+]0 response, attenuated [K+]0 increase and absence of chemosensory nerve discharges. TTX generally did not affect the hypoxic and hypercapnic induced ionic changes, although the [K+]0 undershoot was reduced by 30%. Co2+ competitively blocked the changes in [Ca2+]0 and the increase in the sensory nerve discharge elicited by hypoxia and, not competitively, the changes of [K+]0. The ionic changes to hypercapnia were less affected by Co2+. Ouabain inhibited the [K+]0 undershoot induced hypoxia, as did the removal of Na+ from medium. It is concluded that changes in extracellular free Ca2+ and K+ ions concentration induced by hypoxia and hypercapnia represent ionic fluxes related to the transduction process of carotid body cells (glomus and/or sustentacular)." @default.
- W2012245639 created "2016-06-24" @default.
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- W2012245639 date "1977-12-01" @default.
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- W2012245639 title "The calcium binding sites of dense-core vesicles in the catecholaminergic glomus cells of the rat carotid body" @default.
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- W2012245639 doi "https://doi.org/10.1016/0006-8993(77)90693-x" @default.
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