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- W2012246654 abstract "Aside from central nervous system bleeding, gastrointestinal bleeding (GIB) is a major complication of antiplatelet therapy in stroke patients. A long duration of dual antiplatelets (vs. monotherapy) appears to be a factor leading to increased GIB (1). However, factors related to GIB in patients receiving antiplatelets remain uncertain. Cerebral small-vessel disease (SVD) manifests as lacunes, white matter hyperintensities, enlarged perivascular spaces, and cerebral microbleeds (2). Recent studies have provided evidence that patients with cerebral SVD may have widespread vasculopathy in other organs as well (3), although the clinical expression may be purely neurological. We hypothesized that patients with cerebral SVD may more often develop GIB. We studied patients with cerebral infarction who developed GIB while receiving antiplatelet therapy between May 2007 and May 2013 in a tertiary hospital. Age-and sex-matched control subjects who did not experience GIB were randomly selected from patients attending the outpatient clinic on the same day as the study subjects. Patients receiving anticoagulants were excluded. Brain magnetic resonance images were evaluated for the presence of SVD markers: lacunes, white matter changes, microbleeds, and perivascular spaces. Forty-six patients with GIB and 92 control subjects were enrolled. Between the two groups, no differences were found for the demographic characteristics, vascular risk factors, stroke subtypes, or number of antiplatelets (monotherapy vs. dual therapy). The prevalence of white matter hyperintensities (P = 0·01), lacunes (P = 0·01), and perivascular spaces (P < 0·001) was higher in the GIB group than in control subjects. To avoid multicollinearity among white matter hyperintensities, lacunes, perivascular spaces, and microbleeds, each marker of SVD and SVD itself was individually included in the multivariable analysis, which showed that SVD, white matter hyperintensities, lacunes, and perivascular spaces were independently associated with an increased GIB (Table 1). Our findings suggest that stroke patients with cerebral SVD may have an increased risk of antiplatelet-associated GIB. This may be related to the systemic small vessel pathology in these patients. We may have to be more cautious in choosing the number and dose of antiplatelets in patients with extensive SVD. Further studies with a larger number of patients are required to confirm our preliminary findings." @default.
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- W2012246654 date "2014-09-18" @default.
- W2012246654 modified "2023-10-14" @default.
- W2012246654 title "Cerebral Small Vessel Disease May Be Related to Antiplatelet-Induced Gastrointestinal Bleeding" @default.
- W2012246654 cites W1991655882 @default.
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- W2012246654 doi "https://doi.org/10.1111/ijs.12345" @default.
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