Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012247257> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2012247257 abstract "MicroRNAs (miRNAs) are naturally occurring, short non-coding RNAs believed to be involved in many biological processes including normal development and adult cancer. It seems logical that miRNAs would be particularly important in pediatric cancers as these malignancies generally involve perturbations of normal developmental and differentiation processes, yet relatively little is known about the role of miRNAs in pediatric cancers. Here, we show that oncogenesis in Wilms’ tumor - the most common pediatric renal cancer - is mediated by miRNAs. MiRNA microarray analysis identified a cohort of miRNAs that show altered expression in Wilms’ tumors when compared with normal matched control kidney. Our results reveal that several of these miRNAs show similar expression patterns both in Wilms’ tumors and fetal kidney, suggesting that they may play an important regulatory role in kidney development and Wilms’ tumorigenesis. Supporting this notion are our findings that show a number of differentially expressed miRNAs to target genes known to play a role in kidney development and Wilms’ tumorigenesis, including the Six1 homeobox gene, a potent oncogene reported to be overexpressed in several solid tumors. Analyses of primary Wilms’ tumors and ovarian cancer tissues as well as multiple tumor cell lines from breast cancer, ovarian cancer and rhabdomyosarcoma showed decreased expression of miRNAs targeting the Six1 3′UTR, paralleling an increase in Six1 levels. Further investigation revealed a potent tumor suppressor role for Six1 targeting miRNAs, as ectopic expression suppressed the ability of cancer cell lines to form colonies and tumor growth in nude mice. Interestingly, the reduced expression of these miRNAs in Wilms’ tumors was due in part to genomic loss of loci that contain these miRNAs, as revealed by high resolution comparative genomic hybridization analysis. In summary, our findings suggest that miRNAs are integral to the molecular circuitry that plays an important role in Wilms’ tumorigenesis by regulating events during normal kidney development. In addition, our discovery of novel tumor suppressor miRNAs targeting the Six1 oncogene promises to unravel a unique regulatory mechanism for Six1 deregulation in pediatric as well adult tumors. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2107." @default.
- W2012247257 created "2016-06-24" @default.
- W2012247257 creator A5001777570 @default.
- W2012247257 creator A5007990664 @default.
- W2012247257 creator A5008673283 @default.
- W2012247257 creator A5043640443 @default.
- W2012247257 creator A5060628869 @default.
- W2012247257 creator A5060974352 @default.
- W2012247257 creator A5074570405 @default.
- W2012247257 date "2010-04-15" @default.
- W2012247257 modified "2023-09-25" @default.
- W2012247257 title "Abstract 2107: Deregulation of tumor suppressor miRNAs results in Six1 oncogene overexpression in pediatric and adult human cancers" @default.
- W2012247257 doi "https://doi.org/10.1158/1538-7445.am10-2107" @default.
- W2012247257 hasPublicationYear "2010" @default.
- W2012247257 type Work @default.
- W2012247257 sameAs 2012247257 @default.
- W2012247257 citedByCount "0" @default.
- W2012247257 crossrefType "proceedings-article" @default.
- W2012247257 hasAuthorship W2012247257A5001777570 @default.
- W2012247257 hasAuthorship W2012247257A5007990664 @default.
- W2012247257 hasAuthorship W2012247257A5008673283 @default.
- W2012247257 hasAuthorship W2012247257A5043640443 @default.
- W2012247257 hasAuthorship W2012247257A5060628869 @default.
- W2012247257 hasAuthorship W2012247257A5060974352 @default.
- W2012247257 hasAuthorship W2012247257A5074570405 @default.
- W2012247257 hasConcept C104317684 @default.
- W2012247257 hasConcept C121608353 @default.
- W2012247257 hasConcept C145059251 @default.
- W2012247257 hasConcept C145103041 @default.
- W2012247257 hasConcept C2775999222 @default.
- W2012247257 hasConcept C2777632694 @default.
- W2012247257 hasConcept C2780427987 @default.
- W2012247257 hasConcept C2781018059 @default.
- W2012247257 hasConcept C29537977 @default.
- W2012247257 hasConcept C39845236 @default.
- W2012247257 hasConcept C502942594 @default.
- W2012247257 hasConcept C54355233 @default.
- W2012247257 hasConcept C555283112 @default.
- W2012247257 hasConcept C86803240 @default.
- W2012247257 hasConcept C97037327 @default.
- W2012247257 hasConceptScore W2012247257C104317684 @default.
- W2012247257 hasConceptScore W2012247257C121608353 @default.
- W2012247257 hasConceptScore W2012247257C145059251 @default.
- W2012247257 hasConceptScore W2012247257C145103041 @default.
- W2012247257 hasConceptScore W2012247257C2775999222 @default.
- W2012247257 hasConceptScore W2012247257C2777632694 @default.
- W2012247257 hasConceptScore W2012247257C2780427987 @default.
- W2012247257 hasConceptScore W2012247257C2781018059 @default.
- W2012247257 hasConceptScore W2012247257C29537977 @default.
- W2012247257 hasConceptScore W2012247257C39845236 @default.
- W2012247257 hasConceptScore W2012247257C502942594 @default.
- W2012247257 hasConceptScore W2012247257C54355233 @default.
- W2012247257 hasConceptScore W2012247257C555283112 @default.
- W2012247257 hasConceptScore W2012247257C86803240 @default.
- W2012247257 hasConceptScore W2012247257C97037327 @default.
- W2012247257 hasLocation W20122472571 @default.
- W2012247257 hasOpenAccess W2012247257 @default.
- W2012247257 hasPrimaryLocation W20122472571 @default.
- W2012247257 hasRelatedWork W1002770315 @default.
- W2012247257 hasRelatedWork W1971181206 @default.
- W2012247257 hasRelatedWork W1990272898 @default.
- W2012247257 hasRelatedWork W2025422678 @default.
- W2012247257 hasRelatedWork W2031147075 @default.
- W2012247257 hasRelatedWork W2034153911 @default.
- W2012247257 hasRelatedWork W2063927196 @default.
- W2012247257 hasRelatedWork W2065122194 @default.
- W2012247257 hasRelatedWork W2066447438 @default.
- W2012247257 hasRelatedWork W2100874276 @default.
- W2012247257 hasRelatedWork W2121423242 @default.
- W2012247257 hasRelatedWork W2148251762 @default.
- W2012247257 hasRelatedWork W2164194749 @default.
- W2012247257 hasRelatedWork W2339236561 @default.
- W2012247257 hasRelatedWork W2409279479 @default.
- W2012247257 hasRelatedWork W2884958923 @default.
- W2012247257 hasRelatedWork W3030957780 @default.
- W2012247257 hasRelatedWork W3041482552 @default.
- W2012247257 hasRelatedWork W3088702850 @default.
- W2012247257 hasRelatedWork W3158314120 @default.
- W2012247257 isParatext "false" @default.
- W2012247257 isRetracted "false" @default.
- W2012247257 magId "2012247257" @default.
- W2012247257 workType "article" @default.