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W2012247957 abstract "Using a combined technique of immunocytochemistry and [3H]thymidine autoradiography, we have determined the birth-date of opioid peptide containing neurons in three hypothalamic nuclei. These include proopiomelanocortin neurons (indicated by ACTH immunoreactivity) in the arcuate nucleus, dynorphin A neurons in the supraoptic nucleus, and [Leu]enkephalin neurons in the periventricular nucleus. Arcuate proopiomelanocortin neurons were born very early in embryonic development, with peak heavy [3H]thymidine nuclear labelling occurring on embryonic day E12. Supraoptic dynorphin A neurons were also labelled relatively early (peak at E13). By contrast, [Leu]enkephalin neurons in the periventricular nucleus exhibited peak heavy nuclear labelling on day E14. The results indicate a differential genesis of these three opioid peptide containing neuronal groups in three different hypothalamic nuclei." @default.
W2012247957 created "2016-06-24" @default.
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W2012247957 date "1985-02-01" @default.
W2012247957 modified "2023-10-17" @default.
W2012247957 title "Development of hypothalamic opioid neurons: A combined immunocytochemical and [3H]thymidine autoradiographic study" @default.
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W2012247957 doi "https://doi.org/10.1016/0143-4179(85)90058-7" @default.
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