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• W2012247975 abstract "Aims: We previously reported that the blood‐brain barrier (BBB) function was impaired in vessels in the hippocampus in 3‐month‐old stroke‐prone spontaneously hypertensive rats (SHRSP). In this study, we examined gene and protein expressions of P‐glycoprotein, a representative efflux transporter of cerebral vessels, in the BBB‐damaged hippocampal vessels of SHRSP and in the vessels of Wistar Kyoto (WKY) rats as controls, to clarify roles of the efflux transporter in the BBB‐damaged vessels. Methods: The expression of P‐glycoprotein in hippocampal and cortical samples was examined by real‐time quantitative reverse transcriptase‐polymerase chain reaction (RT‐PCR), Western blotting and immunoelectron microscopic techniques. Results: Real‐time RT‐PCR and Western blotting analyses revealed that the gene and protein expressions of P‐glycoprotein were increased in the hippocampal samples of 3‐month‐old SHRSP compared with hippocampal samples of 3‐month‐old WKY rats or with cortical samples of SHRSP. The gene expression of P‐glycoprotein was also increased in the hippocampal samples of 4‐week‐old SHRSP. Immunoelectron microscopic examination revealed that immunosignals of P‐glycoprotein were seen in the luminal and ab‐luminal cytoplasmic membranes of endothelial cells and the basal lamina, that the labelling density of P‐glycoprotein in the vessel wall was higher in the hippocampus of 3‐month‐old SHRSP than in other groups and that the immunosignals of P‐glycoprotein were occasionally co‐located with those of albumin. Conclusions: These findings indicate that the expression of P‐glycoprotein is increased in BBB‐damaged hippocampal vessels in hypertensive SHRSP compared with those in WKY rats." @default.
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• W2012247975 date "2009-03-05" @default.
• W2012247975 modified "2023-10-15" @default.
• W2012247975 title "The expression of P-glycoprotein is increased in vessels with blood-brain barrier impairment in a stroke-prone hypertensive model" @default.
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• W2012247975 doi "https://doi.org/10.1111/j.1365-2990.2008.00966.x" @default.
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