FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012250018> ?p ?o ?g. }

• W2012250018 endingPage "186" @default.
• W2012250018 startingPage "179" @default.
• W2012250018 abstract "The role of retinoic acid (RA) in limb development is unclear, although it has been suggested to be a proximalizing factor which plays a morphogenetic role in pattern formation. Exogenous RA produces a teratogenic effect on limb morphology; similarly, changes in the endogenous distribution of RA following genetic ablation of the RA-metabolizing enzyme, CYP26B1, result in phocomelia accompanied by changes in expression of proximo-distal (P-D) patterning genes, increased cell death, and delayed chondrocyte maturation. Here we show that disruption of RA receptor (RAR) gamma in a Cyp26b1(-/-) background is able to partially rescue limb skeletal morphology without restoring normal expression of proximo-distal patterning genes. We further show that embryos deficient in CYP26B1 exhibit early localized domains of mesenchymal cell death, which are reduced in compound-null animals. This model reveals two genetically separable effects of RA in the limb: an apoptotic effect mediated by RARgamma in the presence of ectopic RA, and a P-D patterning defect which is uncovered following the loss of both CYP26B1 and RARgamma. These data provide genetic evidence to clarify the roles of both RA and CYP26B1 in limb outgrowth and proximo-distal patterning." @default.
• W2012250018 created "2016-06-24" @default.
• W2012250018 creator A5007684769 @default.
• W2012250018 creator A5012551358 @default.
• W2012250018 creator A5037511237 @default.
• W2012250018 creator A5087874082 @default.
• W2012250018 date "2010-03-01" @default.
• W2012250018 modified "2023-10-07" @default.
• W2012250018 title "Analysis of Cyp26b1/Rarg compound-null mice reveals two genetically separable effects of retinoic acid on limb outgrowth" @default.
• W2012250018 cites W1509243264 @default.
• W2012250018 cites W1527331090 @default.
• W2012250018 cites W1666476357 @default.
• W2012250018 cites W1868208269 @default.
• W2012250018 cites W1939881246 @default.
• W2012250018 cites W1963643849 @default.
• W2012250018 cites W1971136975 @default.
• W2012250018 cites W1971943177 @default.
• W2012250018 cites W1982816939 @default.
• W2012250018 cites W1984960456 @default.
• W2012250018 cites W1999831652 @default.
• W2012250018 cites W2001642371 @default.
• W2012250018 cites W2002923824 @default.
• W2012250018 cites W2030789263 @default.
• W2012250018 cites W2036912330 @default.
• W2012250018 cites W2040213004 @default.
• W2012250018 cites W2053235171 @default.
• W2012250018 cites W2057050837 @default.
• W2012250018 cites W2059532513 @default.
• W2012250018 cites W2064579441 @default.
• W2012250018 cites W2065546357 @default.
• W2012250018 cites W2066219780 @default.
• W2012250018 cites W2071852892 @default.
• W2012250018 cites W2074038170 @default.
• W2012250018 cites W2077853001 @default.
• W2012250018 cites W2093036456 @default.
• W2012250018 cites W2093494317 @default.
• W2012250018 cites W2098159639 @default.
• W2012250018 cites W2103558364 @default.
• W2012250018 cites W2104542540 @default.
• W2012250018 cites W2110873651 @default.
• W2012250018 cites W2112742649 @default.
• W2012250018 cites W2132837491 @default.
• W2012250018 cites W2138434278 @default.
• W2012250018 cites W2147713257 @default.
• W2012250018 cites W2148591887 @default.
• W2012250018 cites W2150080189 @default.
• W2012250018 cites W2151664346 @default.
• W2012250018 cites W2162169187 @default.
• W2012250018 cites W2291668409 @default.
• W2012250018 cites W4236274382 @default.
• W2012250018 doi "https://doi.org/10.1016/j.ydbio.2009.12.024" @default.
• W2012250018 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20043900" @default.
• W2012250018 hasPublicationYear "2010" @default.
• W2012250018 type Work @default.
• W2012250018 sameAs 2012250018 @default.
• W2012250018 citedByCount "26" @default.
• W2012250018 countsByYear W20122500182012 @default.
• W2012250018 countsByYear W20122500182014 @default.
• W2012250018 countsByYear W20122500182015 @default.
• W2012250018 countsByYear W20122500182016 @default.
• W2012250018 countsByYear W20122500182017 @default.
• W2012250018 countsByYear W20122500182019 @default.
• W2012250018 countsByYear W20122500182020 @default.
• W2012250018 countsByYear W20122500182021 @default.
• W2012250018 countsByYear W20122500182022 @default.
• W2012250018 countsByYear W20122500182023 @default.
• W2012250018 crossrefType "journal-article" @default.
• W2012250018 hasAuthorship W2012250018A5007684769 @default.
• W2012250018 hasAuthorship W2012250018A5012551358 @default.
• W2012250018 hasAuthorship W2012250018A5037511237 @default.
• W2012250018 hasAuthorship W2012250018A5087874082 @default.
• W2012250018 hasConcept C102309675 @default.
• W2012250018 hasConcept C104317684 @default.
• W2012250018 hasConcept C196843134 @default.
• W2012250018 hasConcept C2779329299 @default.
• W2012250018 hasConcept C2781121885 @default.
• W2012250018 hasConcept C54355233 @default.
• W2012250018 hasConcept C86370654 @default.
• W2012250018 hasConcept C86803240 @default.
• W2012250018 hasConcept C87073359 @default.
• W2012250018 hasConcept C95444343 @default.
• W2012250018 hasConcept C97037327 @default.
• W2012250018 hasConceptScore W2012250018C102309675 @default.
• W2012250018 hasConceptScore W2012250018C104317684 @default.
• W2012250018 hasConceptScore W2012250018C196843134 @default.
• W2012250018 hasConceptScore W2012250018C2779329299 @default.
• W2012250018 hasConceptScore W2012250018C2781121885 @default.
• W2012250018 hasConceptScore W2012250018C54355233 @default.
• W2012250018 hasConceptScore W2012250018C86370654 @default.
• W2012250018 hasConceptScore W2012250018C86803240 @default.
• W2012250018 hasConceptScore W2012250018C87073359 @default.
• W2012250018 hasConceptScore W2012250018C95444343 @default.
• W2012250018 hasConceptScore W2012250018C97037327 @default.
• W2012250018 hasFunder F4320334506 @default.
• W2012250018 hasIssue "1" @default.
• W2012250018 hasLocation W20122500181 @default.
• W2012250018 hasLocation W20122500182 @default.
• W2012250018 hasOpenAccess W2012250018 @default.

• next