Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012251611> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2012251611 endingPage "238" @default.
- W2012251611 startingPage "230" @default.
- W2012251611 abstract "Isolated human mitochondrial trifunctional protein was incubated with 2-hexadecenoyl-CoA, CoA and NAD+ and the resultant CoA esters measured. Steady state with respect to the concentrations of the intermediates 3-hydroxyhexadecanoyl-CoA and 3-ketohexadecanoyl-CoA and the rate of formation of the product tetradecanoyl-CoA was reached within 4 min. Flux was greatly enhanced by the addition of Tween 20 (0.2% v/v) which stimulated 3-ketoacyl-CoA thiolase activity by over 7-fold. When 3-ketoacyl-CoA thiolase was not stimulated, 3-hydroxyhexadecanoyl-CoA was the prominent CoA ester accumulated, presumably due to inhibition of 3-hydroxyacyl-CoA dehydrogenase activity by accumulated 3-ketoacyl-CoA, analogous to the inhibition of short-chain 3-hydroxyacyl-CoA dehydrogenase by 3-ketoacyl-CoA. When [NAD+]/[NADH] was varied at a fixed total [NAD++NADH], the overall flux was only inhibited by [NAD+]/[NADH] less than 1. In contrast, when [acetyl-CoA]/[CoA] was varied at a fixed total [CoA], much greater sensitivity was observed." @default.
- W2012251611 created "2016-06-24" @default.
- W2012251611 creator A5034415637 @default.
- W2012251611 creator A5042706357 @default.
- W2012251611 creator A5058744331 @default.
- W2012251611 date "1998-12-01" @default.
- W2012251611 modified "2023-10-16" @default.
- W2012251611 title "Control of mitochondrial β-oxidation: sensitivity of the trifunctional protein to [NAD+]/[NADH] and [acetyl-CoA]/[CoA]" @default.
- W2012251611 cites W122853067 @default.
- W2012251611 cites W1433059225 @default.
- W2012251611 cites W1490813990 @default.
- W2012251611 cites W1510158417 @default.
- W2012251611 cites W1560517732 @default.
- W2012251611 cites W1562882576 @default.
- W2012251611 cites W1677773489 @default.
- W2012251611 cites W1858562613 @default.
- W2012251611 cites W1952321278 @default.
- W2012251611 cites W195658009 @default.
- W2012251611 cites W1982026595 @default.
- W2012251611 cites W1991710402 @default.
- W2012251611 cites W1994717451 @default.
- W2012251611 cites W1997774441 @default.
- W2012251611 cites W2013562963 @default.
- W2012251611 cites W2023691876 @default.
- W2012251611 cites W2031535248 @default.
- W2012251611 cites W2040271350 @default.
- W2012251611 cites W2054334375 @default.
- W2012251611 cites W2062305414 @default.
- W2012251611 cites W2074435742 @default.
- W2012251611 cites W2077462875 @default.
- W2012251611 cites W2132170319 @default.
- W2012251611 cites W2132179158 @default.
- W2012251611 cites W2158807341 @default.
- W2012251611 cites W2204411178 @default.
- W2012251611 cites W2212175354 @default.
- W2012251611 cites W2407233542 @default.
- W2012251611 cites W72536532 @default.
- W2012251611 doi "https://doi.org/10.1016/s0167-4838(98)00246-5" @default.
- W2012251611 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9920399" @default.
- W2012251611 hasPublicationYear "1998" @default.
- W2012251611 type Work @default.
- W2012251611 sameAs 2012251611 @default.
- W2012251611 citedByCount "23" @default.
- W2012251611 countsByYear W20122516112014 @default.
- W2012251611 countsByYear W20122516112015 @default.
- W2012251611 countsByYear W20122516112018 @default.
- W2012251611 countsByYear W20122516112019 @default.
- W2012251611 countsByYear W20122516112022 @default.
- W2012251611 countsByYear W20122516112023 @default.
- W2012251611 crossrefType "journal-article" @default.
- W2012251611 hasAuthorship W2012251611A5034415637 @default.
- W2012251611 hasAuthorship W2012251611A5042706357 @default.
- W2012251611 hasAuthorship W2012251611A5058744331 @default.
- W2012251611 hasConcept C181199279 @default.
- W2012251611 hasConcept C185592680 @default.
- W2012251611 hasConcept C2776317432 @default.
- W2012251611 hasConcept C2778470496 @default.
- W2012251611 hasConcept C2781031557 @default.
- W2012251611 hasConcept C45566312 @default.
- W2012251611 hasConcept C55493867 @default.
- W2012251611 hasConcept C75520062 @default.
- W2012251611 hasConceptScore W2012251611C181199279 @default.
- W2012251611 hasConceptScore W2012251611C185592680 @default.
- W2012251611 hasConceptScore W2012251611C2776317432 @default.
- W2012251611 hasConceptScore W2012251611C2778470496 @default.
- W2012251611 hasConceptScore W2012251611C2781031557 @default.
- W2012251611 hasConceptScore W2012251611C45566312 @default.
- W2012251611 hasConceptScore W2012251611C55493867 @default.
- W2012251611 hasConceptScore W2012251611C75520062 @default.
- W2012251611 hasIssue "1" @default.
- W2012251611 hasLocation W20122516111 @default.
- W2012251611 hasLocation W20122516112 @default.
- W2012251611 hasOpenAccess W2012251611 @default.
- W2012251611 hasPrimaryLocation W20122516111 @default.
- W2012251611 hasRelatedWork W1997774441 @default.
- W2012251611 hasRelatedWork W2012251611 @default.
- W2012251611 hasRelatedWork W2033494319 @default.
- W2012251611 hasRelatedWork W2042952277 @default.
- W2012251611 hasRelatedWork W2076799412 @default.
- W2012251611 hasRelatedWork W2085598782 @default.
- W2012251611 hasRelatedWork W2155629021 @default.
- W2012251611 hasRelatedWork W2260682124 @default.
- W2012251611 hasRelatedWork W2397786582 @default.
- W2012251611 hasRelatedWork W88301565 @default.
- W2012251611 hasVolume "1429" @default.
- W2012251611 isParatext "false" @default.
- W2012251611 isRetracted "false" @default.
- W2012251611 magId "2012251611" @default.
- W2012251611 workType "article" @default.