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• W2012251844 abstract "During diabetes mellitus, total proteins and ribonucleic acids are significantly decreased in the rat heart, and these parameters can be increased by insulin administration. To determine whether all ribonucleic acids are equally sensitive to insulin, we examined the influence of this hormone on individual translatable ribonucleic acids. Cardiac ribonucleic acid prepared from control, untreated, and insulin-treated diabetic animals was translated in vitro in the presence of [35S]methionine. The radiolabeled peptides were separated by two-dimensional gel electrophoresis and were analyzed by fluorometry. We found that diabetes induces both qualitative and quantitative changes in the predominance of a few specific translatable messenger ribonucleic acid species. The translation of 11 messenger ribonucleic acid species was significantly decreased and that of eight messenger ribonucleic acid species was significantly increased in diabetic preparation. Twelve of the 19 translation products were quantified by digital matrix photometry: three labeled peptides were observed only when cardiac ribonucleic acid from diabetic animals was added to the cell-free translation system, four new peptides appeared when cardiac ribonucleic acid from control animals was added, and although the remaining five peptides were translated in vitro after either control or diabetic ribonucleic acid was added, their relative predominance was altered 2- to 200-fold. When translation products coded for by messenger ribonucleic acids prepared from either diabetic or hypothyroid hearts were compared, we found that most of the alterations induced by diabetes were also induced by hypothyroidism.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
• W2012251844 created "2016-06-24" @default.
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• W2012251844 date "1985-08-01" @default.
• W2012251844 modified "2023-10-14" @default.
• W2012251844 title "Diabetes-induced alterations in the translational activity of specific messenger ribonucleic acids isolated from rat hearts." @default.
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• W2012251844 doi "https://doi.org/10.1161/01.res.57.2.296" @default.
• W2012251844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4017199" @default.
• W2012251844 hasPublicationYear "1985" @default.
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