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- W2012252019 abstract "Based on 92537 blood samples received from 7365 patients with a request for a meningococcal antibody test (MAT) during a 10-year period (1986–1995), the usefulness of the test in the diagnosis of meningococcal disease was assessed. Of 635 patients with culture-confirmed meningococcal disease, 88% were seronegative on admittance to hospital and 90% were seropositive 10–15 days after onset of disease. The humoral immune response in children <2 years of age was weaker than in older children and adults. Among 893 MAT-positive patients without culture-confirmed meningococcal disease, 261 (29%) had been notified as cases of meningococcal disease. Among 228 patients notified as serologically confirmed the MAT results were consistent with the clinical diagnosis in 86%. MAT is a reliable tool for establishing a diagnosis in patients with suspected meningococcal disease. Key factors facilitating appropriate interpretation of negative as well as positive test results were: time(s) of sampling(s) after onset of disease, age of the patient and clinical features." @default.
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- W2012252019 date "2004-12-22" @default.
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- W2012252019 title "The meningococcal antibody test: how useful in the diagnosis of meningococcal disease?" @default.
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- W2012252019 doi "https://doi.org/10.1017/s0950268804003425" @default.
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