FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W201225377> ?p ?o ?g. }

• W201225377 endingPage "794" @default.
• W201225377 startingPage "789" @default.
• W201225377 abstract "Histamine (0.5 mM) stimulated the cyclic AMP content of cell suspensions containing greater than 80% parietal cells. Epidermal growth factor (EGF) inhibited this stimulatory effect of histamine, but had no effect on basal cyclic AMP content. The half-maximally effective concentration of EGF for inhibition of histamine-stimulated cyclic AMP was 3.9 nM. The equivalent measurement for the inhibition of histamine-stimulated aminopyrine accumulation was 3.0 nM. Aminopyrine accumulation was measured because it provides an index of the secretory activity of the cell. The cyclic AMP phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine (IBMX) prevented the inhibitory effect of EGF on cyclic AMP content. This effect of IBMX was not caused by its ability to raise cellular cyclic AMP content in the presence of histamine. Prevention by IBMX of the inhibitory action of EGF on histamine-stimulated aminopyrine accumulation had been shown previously [Shaw, Hatt, Anderson & Hanson (1987) Biochem. J. 244, 699-704]. EGF stimulated prostaglandin E2 (PGE2) production in the cell fraction containing greater than 80% parietal cells, with the half-maximally effective concentration being 7.5 nM. EGF was ineffective in stimulating PGE2 production if the cell fraction was depleted of parietal cells (12%), or if 0.5 mM-histamine was added to the enriched parietal-cell fraction. In conclusion, EGF may inhibit histamine-stimulated acid secretion by decreasing the cyclic AMP content of parietal cells. This effect could be mediated by an increase in cyclic AMP phosphodiesterase activity, but it is unlikely to involve an effect of EGF on parietal-cell prostaglandin production." @default.
• W201225377 created "2016-06-24" @default.
• W201225377 creator A5001558406 @default.
• W201225377 creator A5052393900 @default.
• W201225377 date "1988-11-01" @default.
• W201225377 modified "2023-09-23" @default.
• W201225377 title "Inhibition of gastric acid secretion by epidermal growth factor. Effects on cyclic AMP and on prostaglandin production in rat isolated parietal cells" @default.
• W201225377 cites W1972509294 @default.
• W201225377 cites W1975343174 @default.
• W201225377 cites W1977943107 @default.
• W201225377 cites W1991274673 @default.
• W201225377 cites W1993330326 @default.
• W201225377 cites W2011993999 @default.
• W201225377 cites W2023943100 @default.
• W201225377 cites W2025187945 @default.
• W201225377 cites W2026931973 @default.
• W201225377 cites W2027825011 @default.
• W201225377 cites W2060881470 @default.
• W201225377 cites W2072943621 @default.
• W201225377 cites W2072990648 @default.
• W201225377 cites W2135997385 @default.
• W201225377 cites W2231298982 @default.
• W201225377 cites W2313259423 @default.
• W201225377 cites W2323733023 @default.
• W201225377 cites W2355690497 @default.
• W201225377 cites W2417999608 @default.
• W201225377 cites W2418556670 @default.
• W201225377 cites W2462920353 @default.
• W201225377 cites W82133889 @default.
• W201225377 doi "https://doi.org/10.1042/bj2550789" @default.
• W201225377 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1135310" @default.
• W201225377 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2463831" @default.
• W201225377 hasPublicationYear "1988" @default.
• W201225377 type Work @default.
• W201225377 sameAs 201225377 @default.
• W201225377 citedByCount "18" @default.
• W201225377 crossrefType "journal-article" @default.
• W201225377 hasAuthorship W201225377A5001558406 @default.
• W201225377 hasAuthorship W201225377A5052393900 @default.
• W201225377 hasBestOaLocation W2012253772 @default.
• W201225377 hasConcept C1122143 @default.
• W201225377 hasConcept C126322002 @default.
• W201225377 hasConcept C134018914 @default.
• W201225377 hasConcept C170493617 @default.
• W201225377 hasConcept C181199279 @default.
• W201225377 hasConcept C185592680 @default.
• W201225377 hasConcept C24998067 @default.
• W201225377 hasConcept C2776362946 @default.
• W201225377 hasConcept C2776766087 @default.
• W201225377 hasConcept C2777198256 @default.
• W201225377 hasConcept C2777504413 @default.
• W201225377 hasConcept C2777956040 @default.
• W201225377 hasConcept C2779276759 @default.
• W201225377 hasConcept C2779743957 @default.
• W201225377 hasConcept C2780664492 @default.
• W201225377 hasConcept C2781298581 @default.
• W201225377 hasConcept C49039625 @default.
• W201225377 hasConcept C55493867 @default.
• W201225377 hasConcept C62826618 @default.
• W201225377 hasConcept C71924100 @default.
• W201225377 hasConcept C86803240 @default.
• W201225377 hasConceptScore W201225377C1122143 @default.
• W201225377 hasConceptScore W201225377C126322002 @default.
• W201225377 hasConceptScore W201225377C134018914 @default.
• W201225377 hasConceptScore W201225377C170493617 @default.
• W201225377 hasConceptScore W201225377C181199279 @default.
• W201225377 hasConceptScore W201225377C185592680 @default.
• W201225377 hasConceptScore W201225377C24998067 @default.
• W201225377 hasConceptScore W201225377C2776362946 @default.
• W201225377 hasConceptScore W201225377C2776766087 @default.
• W201225377 hasConceptScore W201225377C2777198256 @default.
• W201225377 hasConceptScore W201225377C2777504413 @default.
• W201225377 hasConceptScore W201225377C2777956040 @default.
• W201225377 hasConceptScore W201225377C2779276759 @default.
• W201225377 hasConceptScore W201225377C2779743957 @default.
• W201225377 hasConceptScore W201225377C2780664492 @default.
• W201225377 hasConceptScore W201225377C2781298581 @default.
• W201225377 hasConceptScore W201225377C49039625 @default.
• W201225377 hasConceptScore W201225377C55493867 @default.
• W201225377 hasConceptScore W201225377C62826618 @default.
• W201225377 hasConceptScore W201225377C71924100 @default.
• W201225377 hasConceptScore W201225377C86803240 @default.
• W201225377 hasIssue "3" @default.
• W201225377 hasLocation W2012253771 @default.
• W201225377 hasLocation W2012253772 @default.
• W201225377 hasLocation W2012253773 @default.
• W201225377 hasLocation W2012253774 @default.
• W201225377 hasOpenAccess W201225377 @default.
• W201225377 hasPrimaryLocation W2012253771 @default.
• W201225377 hasRelatedWork W1982310992 @default.
• W201225377 hasRelatedWork W1988418183 @default.
• W201225377 hasRelatedWork W2006844127 @default.
• W201225377 hasRelatedWork W2009453098 @default.
• W201225377 hasRelatedWork W2011375238 @default.
• W201225377 hasRelatedWork W201225377 @default.
• W201225377 hasRelatedWork W2016034363 @default.
• W201225377 hasRelatedWork W2056100207 @default.
• W201225377 hasRelatedWork W2114445653 @default.

• next