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- W2012253784 abstract "Despite the fact that the mutations in K -ras codon 12 and TP53 are common abnormalities in colorectal cancer, the determination of K -ras mutation combined with TP53 gene mutation, with diagnostic and prognostic purposes is still controversial. We have analyzed K-ras and TP53 mutations in 77 sporadic colorectal adenocarcinomas by means of polymerase chain reaction and sequencing. We observed a negative correlation between both K-ras and TP53 mutations. Patients with mutations in K-ras but not in TP53 exhibited worse survival rates than those with mutations in TP53 and not in K-ras. Moreover, we found the worst outcome in patients with mutations in both K-ras and TP53. These results may relate to the previously published data about primary human and rodent cells, in which transformation by Ras require either a cooperating oncogene or the inactivation of tumor suppressors such as p53 or p16. In conclusion, simultaneous mutations in K-ras and TP53 are indicative of a worse prognosis in sporadic colorectal cancer." @default.
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- W2012253784 date "2004-02-01" @default.
- W2012253784 modified "2023-09-25" @default.
- W2012253784 title "Simultaneous Mutations in K-ras and TP53 Are Indicative of Poor Prognosis in Sporadic Colorectal Cancer" @default.
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- W2012253784 doi "https://doi.org/10.1097/01.coc.0000045920.49210.7a" @default.
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