Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012256194> ?p ?o ?g. }
- W2012256194 endingPage "7115" @default.
- W2012256194 startingPage "7113" @default.
- W2012256194 abstract "We describe herein an efficient new route to the trikentrins and their related structures using a tandem 6,7-indolyne cycloaddition/Negishi cross-coupling reaction starting from a 4,6,7-tribromoindole (obtained in good yield via the Bartoli indole synthesis). The key step of this second generation route to the trikentrins is based on our observation that the 7-bromo substituent appears to undergo selective metal–halogen exchange and elimination to give the 6,7-indolyne, which is trapped in the presence of excess cyclopentadiene. Subsequent Negishi cross-coupling at the 4-bromoindole position with Et2Zn gave directly the same intermediate obtained from our previous work. Application of this chemistry to the construction of trikentrin-related libraries using this general cycloaddition/cross-coupling tactic will also be described." @default.
- W2012256194 created "2016-06-24" @default.
- W2012256194 creator A5002071446 @default.
- W2012256194 creator A5017792294 @default.
- W2012256194 creator A5039054387 @default.
- W2012256194 creator A5052264404 @default.
- W2012256194 date "2009-12-01" @default.
- W2012256194 modified "2023-10-10" @default.
- W2012256194 title "New synthesis of (±)-cis-trikentrin A via tandem indole aryne cycloaddition/Negishi reaction. Applications to library development" @default.
- W2012256194 cites W1963720844 @default.
- W2012256194 cites W1965878570 @default.
- W2012256194 cites W1967048565 @default.
- W2012256194 cites W1989559404 @default.
- W2012256194 cites W2001838516 @default.
- W2012256194 cites W2011481911 @default.
- W2012256194 cites W2015612733 @default.
- W2012256194 cites W2017307957 @default.
- W2012256194 cites W2051556078 @default.
- W2012256194 cites W2052801348 @default.
- W2012256194 cites W2064963188 @default.
- W2012256194 cites W2068604931 @default.
- W2012256194 cites W2069361917 @default.
- W2012256194 cites W2070158040 @default.
- W2012256194 cites W2090868382 @default.
- W2012256194 cites W2094354437 @default.
- W2012256194 cites W2114729442 @default.
- W2012256194 cites W2118589642 @default.
- W2012256194 cites W2151233220 @default.
- W2012256194 cites W2949576769 @default.
- W2012256194 cites W2950118514 @default.
- W2012256194 cites W2950534998 @default.
- W2012256194 cites W4380248477 @default.
- W2012256194 doi "https://doi.org/10.1016/j.tetlet.2009.09.083" @default.
- W2012256194 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2945378" @default.
- W2012256194 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20877442" @default.
- W2012256194 hasPublicationYear "2009" @default.
- W2012256194 type Work @default.
- W2012256194 sameAs 2012256194 @default.
- W2012256194 citedByCount "37" @default.
- W2012256194 countsByYear W20122561942012 @default.
- W2012256194 countsByYear W20122561942013 @default.
- W2012256194 countsByYear W20122561942014 @default.
- W2012256194 countsByYear W20122561942015 @default.
- W2012256194 countsByYear W20122561942016 @default.
- W2012256194 countsByYear W20122561942018 @default.
- W2012256194 countsByYear W20122561942019 @default.
- W2012256194 countsByYear W20122561942020 @default.
- W2012256194 countsByYear W20122561942021 @default.
- W2012256194 crossrefType "journal-article" @default.
- W2012256194 hasAuthorship W2012256194A5002071446 @default.
- W2012256194 hasAuthorship W2012256194A5017792294 @default.
- W2012256194 hasAuthorship W2012256194A5039054387 @default.
- W2012256194 hasAuthorship W2012256194A5052264404 @default.
- W2012256194 hasBestOaLocation W20122561942 @default.
- W2012256194 hasConcept C134121241 @default.
- W2012256194 hasConcept C159985019 @default.
- W2012256194 hasConcept C161790260 @default.
- W2012256194 hasConcept C171811041 @default.
- W2012256194 hasConcept C178790620 @default.
- W2012256194 hasConcept C185592680 @default.
- W2012256194 hasConcept C191897082 @default.
- W2012256194 hasConcept C192527728 @default.
- W2012256194 hasConcept C192562407 @default.
- W2012256194 hasConcept C21951064 @default.
- W2012256194 hasConcept C2777814067 @default.
- W2012256194 hasConcept C2778689049 @default.
- W2012256194 hasConcept C2779664164 @default.
- W2012256194 hasConcept C2780263894 @default.
- W2012256194 hasConcept C46062151 @default.
- W2012256194 hasConcept C71240020 @default.
- W2012256194 hasConcept C71866858 @default.
- W2012256194 hasConceptScore W2012256194C134121241 @default.
- W2012256194 hasConceptScore W2012256194C159985019 @default.
- W2012256194 hasConceptScore W2012256194C161790260 @default.
- W2012256194 hasConceptScore W2012256194C171811041 @default.
- W2012256194 hasConceptScore W2012256194C178790620 @default.
- W2012256194 hasConceptScore W2012256194C185592680 @default.
- W2012256194 hasConceptScore W2012256194C191897082 @default.
- W2012256194 hasConceptScore W2012256194C192527728 @default.
- W2012256194 hasConceptScore W2012256194C192562407 @default.
- W2012256194 hasConceptScore W2012256194C21951064 @default.
- W2012256194 hasConceptScore W2012256194C2777814067 @default.
- W2012256194 hasConceptScore W2012256194C2778689049 @default.
- W2012256194 hasConceptScore W2012256194C2779664164 @default.
- W2012256194 hasConceptScore W2012256194C2780263894 @default.
- W2012256194 hasConceptScore W2012256194C46062151 @default.
- W2012256194 hasConceptScore W2012256194C71240020 @default.
- W2012256194 hasConceptScore W2012256194C71866858 @default.
- W2012256194 hasIssue "51" @default.
- W2012256194 hasLocation W20122561941 @default.
- W2012256194 hasLocation W20122561942 @default.
- W2012256194 hasLocation W20122561943 @default.
- W2012256194 hasLocation W20122561944 @default.
- W2012256194 hasOpenAccess W2012256194 @default.
- W2012256194 hasPrimaryLocation W20122561941 @default.
- W2012256194 hasRelatedWork W1893811866 @default.
- W2012256194 hasRelatedWork W1967671731 @default.
- W2012256194 hasRelatedWork W1970470365 @default.