FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012256912> ?p ?o ?g. }

• W2012256912 endingPage "112" @default.
• W2012256912 startingPage "103" @default.
• W2012256912 abstract "In view of the critical role played by bacillus Calmette-Guérin (BCG) in the development and functional activation of protective T cells against tuberculosis, it has become important to understand the mechanisms by which cytokines regulate BCG-mediated immune responses. There is evidence that cytokine-mediated suppression of T cell function by mechanisms, including apoptosis, may reduce host resistance in tuberculosis. However, it is unclear whether cytokine-mediated suppression of antigen-responsive T cells through apoptotic mechanisms may be operating during human cellular activation induced by BCG. Here we present evidence, for the first time, that treatment of BCG-activated T cells with transforming growth factor-beta (TGF-beta) induces cellular apoptosis. These results were further supported by the fact that treatment of cells with a blocking mAb directed to TGF-beta significantly inhibited the percentage of apoptosis induced by TGF-beta. Interestingly, TGF-beta-mediated death of BCG-activated T cells in cultures containing interleukin (IL)-12 was observed. Moreover, our results demonstrated the induction of apoptosis by TGF-beta in BCG-activated T cells cultured in the presence of exogenous IL-12. In addition, our data indicated that TGF-beta significantly inhibited both BCG-induced cell growth determined by thymidine uptake and BCG-induced IFN-gamma secretion. Finally, TGF-beta-induced apoptosis in BCG-activated T cells correlated inversely with BCG-induced IFN-gamma secretion. Taken together, these findings indicate that TGF-beta induces apoptosis in human T cells activated with BCG and at the same time suggest that loss of BCG-reactive T cells through apoptotic mechanisms could contribute to an increased susceptibility to Mycobacterium tuberculosis infection." @default.
• W2012256912 created "2016-06-24" @default.
• W2012256912 creator A5000903764 @default.
• W2012256912 creator A5029918782 @default.
• W2012256912 creator A5089389058 @default.
• W2012256912 date "2000-06-01" @default.
• W2012256912 modified "2023-09-25" @default.
• W2012256912 title "Induction of Apoptosis in Bacillus Calmette–Guérin-Activated T Cells by Transforming Growth Factor-β" @default.
• W2012256912 cites W1487729161 @default.
• W2012256912 cites W1487921725 @default.
• W2012256912 cites W1491478405 @default.
• W2012256912 cites W1494055834 @default.
• W2012256912 cites W1522700610 @default.
• W2012256912 cites W1577234690 @default.
• W2012256912 cites W1588621515 @default.
• W2012256912 cites W1600526298 @default.
• W2012256912 cites W1760231445 @default.
• W2012256912 cites W1898764189 @default.
• W2012256912 cites W1905010555 @default.
• W2012256912 cites W2000739442 @default.
• W2012256912 cites W2011384825 @default.
• W2012256912 cites W2023809975 @default.
• W2012256912 cites W2029897352 @default.
• W2012256912 cites W2032980904 @default.
• W2012256912 cites W2036817346 @default.
• W2012256912 cites W2057617426 @default.
• W2012256912 cites W2060098138 @default.
• W2012256912 cites W2070470162 @default.
• W2012256912 cites W2078025711 @default.
• W2012256912 cites W2082386765 @default.
• W2012256912 cites W2085562484 @default.
• W2012256912 cites W2098700395 @default.
• W2012256912 cites W2099985524 @default.
• W2012256912 cites W2110301209 @default.
• W2012256912 cites W2118857294 @default.
• W2012256912 cites W2144217393 @default.
• W2012256912 cites W2146600581 @default.
• W2012256912 cites W2151243547 @default.
• W2012256912 cites W2154122248 @default.
• W2012256912 cites W2164734343 @default.
• W2012256912 cites W2245910568 @default.
• W2012256912 cites W2423696409 @default.
• W2012256912 cites W4312861399 @default.
• W2012256912 doi "https://doi.org/10.1006/cimm.2000.1662" @default.
• W2012256912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10896770" @default.
• W2012256912 hasPublicationYear "2000" @default.
• W2012256912 type Work @default.
• W2012256912 sameAs 2012256912 @default.
• W2012256912 citedByCount "15" @default.
• W2012256912 countsByYear W20122569122012 @default.
• W2012256912 countsByYear W20122569122022 @default.
• W2012256912 crossrefType "journal-article" @default.
• W2012256912 hasAuthorship W2012256912A5000903764 @default.
• W2012256912 hasAuthorship W2012256912A5029918782 @default.
• W2012256912 hasAuthorship W2012256912A5089389058 @default.
• W2012256912 hasConcept C118131993 @default.
• W2012256912 hasConcept C134018914 @default.
• W2012256912 hasConcept C149532602 @default.
• W2012256912 hasConcept C154317977 @default.
• W2012256912 hasConcept C190283241 @default.
• W2012256912 hasConcept C202751555 @default.
• W2012256912 hasConcept C203014093 @default.
• W2012256912 hasConcept C2778229498 @default.
• W2012256912 hasConcept C2778690821 @default.
• W2012256912 hasConcept C49039625 @default.
• W2012256912 hasConcept C502942594 @default.
• W2012256912 hasConcept C55493867 @default.
• W2012256912 hasConcept C86803240 @default.
• W2012256912 hasConcept C8891405 @default.
• W2012256912 hasConcept C95444343 @default.
• W2012256912 hasConceptScore W2012256912C118131993 @default.
• W2012256912 hasConceptScore W2012256912C134018914 @default.
• W2012256912 hasConceptScore W2012256912C149532602 @default.
• W2012256912 hasConceptScore W2012256912C154317977 @default.
• W2012256912 hasConceptScore W2012256912C190283241 @default.
• W2012256912 hasConceptScore W2012256912C202751555 @default.
• W2012256912 hasConceptScore W2012256912C203014093 @default.
• W2012256912 hasConceptScore W2012256912C2778229498 @default.
• W2012256912 hasConceptScore W2012256912C2778690821 @default.
• W2012256912 hasConceptScore W2012256912C49039625 @default.
• W2012256912 hasConceptScore W2012256912C502942594 @default.
• W2012256912 hasConceptScore W2012256912C55493867 @default.
• W2012256912 hasConceptScore W2012256912C86803240 @default.
• W2012256912 hasConceptScore W2012256912C8891405 @default.
• W2012256912 hasConceptScore W2012256912C95444343 @default.
• W2012256912 hasIssue "2" @default.
• W2012256912 hasLocation W20122569121 @default.
• W2012256912 hasLocation W20122569122 @default.
• W2012256912 hasOpenAccess W2012256912 @default.
• W2012256912 hasPrimaryLocation W20122569121 @default.
• W2012256912 hasRelatedWork W181678093 @default.
• W2012256912 hasRelatedWork W2005666125 @default.
• W2012256912 hasRelatedWork W2038201520 @default.
• W2012256912 hasRelatedWork W2047209980 @default.
• W2012256912 hasRelatedWork W2059239871 @default.
• W2012256912 hasRelatedWork W2113707229 @default.
• W2012256912 hasRelatedWork W3138050922 @default.
• W2012256912 hasRelatedWork W2084040027 @default.

• next