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- W2012257028 abstract "Matrix metalloproteinases degrade the extracellular matrix and are involved in a variety of diseases, including inflammatory diseases of the central nervous system. Here we estimated the content of gelatinase in rat brain under control conditions and 4 h after transient focal ischemia using gelatinolytic extraction and zymographic analysis. We also examined the expression of the MMP-9 and MMP-2 proteins by Western blot. Using the zymographic apparent gelatinase activity we estimated that brain gelatinase content was 0.44 ng/mg of protein. Ischemia induced a 1.7-fold increase at 4 h, thus showing an early MMP response to the ischemic injury. The main increase was seen for the MMP-9 proform, which was accompanied by enhanced MMP-9 protein expression. We suggest that basal cerebral MMP-9 and MMP-2 activities are involved in the maintenance of the extracellular matrix and prevent substrate accumulation, while enhanced postischemic MMP activity before cell death may contribute to edema formation and blood-brain barrier breakdown." @default.
- W2012257028 created "2016-06-24" @default.
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- W2012257028 date "2000-11-01" @default.
- W2012257028 modified "2023-10-16" @default.
- W2012257028 title "Estimation of Gelatinase Content in Rat Brain: Effect of Focal Ischemia" @default.
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- W2012257028 doi "https://doi.org/10.1006/bbrc.2000.3881" @default.
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