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- W2012257188 abstract "Partial nephrectomy (PN) has gained popularity due to the increased incidenceof small incidental renal tumoursandthe procedure’s excellent oncologic results; however, current scientific evidence suggests that preservation of renal function should be given priority. Go and al [1] showed an independent, gradedassociation between reduced estimated glomerular filtration rate (GFR) and the risks of cardiovascular events, hospitalisation, and death from any cause in a large community-based population. Radical nephrectomy is now understood as a risk factor for chronic kidney disease, which in turn increases the risk of cardiovascular events and all-cause mortality. Huang et al [2] demonstrated in 662 patient-candidates for radical nephrectomy or PN that 26% had a certain degree of impaired renal function at baseline. This study also highlighted that the risk of new onset of chronickidneydiseasewas significantly increased inpatients undergoing radical nephrectomy versus PN. Four recent series have confirmed that patients treated with radical nephrectomy are at increased risk of non–cancer-related death when compared with those being treated with PN. Specifically, Weight et al [3] demonstrated that in patients with T1b tumours, the average excess loss of renal function observed with radical nephrectomy was associated with a 25% increased riskof cardiacdeathanda17% increased riskof death from any cause. These accumulated data should prompt us to choose options that are less deleterious to renal function when determining treatment for small renal tumours. It is obvious thata certainnumberof small renal tumoursare indolentand not life threatening; therefore, we should integrate information such as age, comorbidities, baseline renal function," @default.
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- W2012257188 date "2010-09-01" @default.
- W2012257188 modified "2023-10-01" @default.
- W2012257188 title "Warm Ischaemia: The Ultimate Enemy for Partial Nephrectomy?" @default.
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- W2012257188 doi "https://doi.org/10.1016/j.eururo.2010.07.002" @default.
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