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• W2012257522 abstract "No AccessJournal of UrologyAdult Urology1 Oct 2012Seminal Clusterin Gene Expression Associated with Seminal Variables in Fertile and Infertile Men Adel Zalata, Ayman Z. El-Samanoudy, Dalia Shaalan, Youssef El-Baiomy, Mai Taymour, and Taymour Mostafa Adel ZalataAdel Zalata Medical Biochemistry Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt More articles by this author , Ayman Z. El-SamanoudyAyman Z. El-Samanoudy Medical Biochemistry Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt More articles by this author , Dalia ShaalanDalia Shaalan Medical Biochemistry Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt More articles by this author , Youssef El-BaiomyYoussef El-Baiomy Dermatology and Andrology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt More articles by this author , Mai TaymourMai Taymour Cairo University Hospitals, Cairo University, Cairo, Egypt More articles by this author , and Taymour MostafaTaymour Mostafa Andrology and Sexology Department, Faculty of Medicine, Cairo University, Cairo, Egypt More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2012.06.012AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: CLU is a disulfide linked, heterodimeric protein associated with the clearance of cellular debris and apoptosis. We assessed the association of seminal CLU gene expression with seminal variables in fertile and infertile men. Materials and Methods: A total of 124 men were divided into healthy, fertile men with normozoospermia, and men with asthenozoospermia, asthenoteratozoospermia and oligoasthenoteratozoospermia. History was obtained, and clinical examination and semen analysis were done. In semen we assessed sperm acrosin activity, sperm DNA fragmentation and seminal CLU gene expression. Results: CLU RNA and CLU protein gene expression were significantly increased in semen samples of infertile men with oligoasthenoteratozoospermia > asthenoteratozoospermia > asthenozoospermia compared with healthy, fertile controls. CLU gene expression significantly correlated negatively with sperm count, motility, acrosin activity index, linearity index and linear velocity, and significantly correlated positively with the percent of sperm abnormal forms and DNA fragmentation. Conclusion: CLU gene expression was significantly increased in the semen samples of infertile men. It correlated negatively with sperm count, motility, acrosin activity, linearity index and linear velocity, and positively with the percent of sperm abnormal forms and DNA fragmentation. References 1 : Programmed cell death in varicocele-bearing testes. Andrologia2009; 41: 39. Google Scholar 2 : Soluble Fas and gonadal hormones in infertile men with varicocele. Fertil Steril2009; 91: 420. Google Scholar 3 : Establishment of male-specific epigenetic information. Gene2005; 345: 139. Google Scholar 4 : Clusterin/apolipoprotein J in human aging and cancer. Int J Biochem Cell Biol2002; 34: 1430. Google Scholar 5 : Characterization and functional consequences of underexpression of clusterin in rheumatoid arthritis. J Immunol2006; 177: 6471. Google Scholar 6 : Sandwich ELISA assay for quantitative measurement of SP-40, 40 in seminal plasma and serum. J Immunol Methods1990; 131: 159. 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Google Scholar © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byAtala A (2018) Re: Missense Mutations in SLC26A8, Encoding a Sperm-Specific Activator of CFTR, are Associated with Human AsthenozoospermiaJournal of Urology, VOL. 191, NO. 2, (554-555), Online publication date: 1-Feb-2014. Volume 188Issue 4October 2012Page: 1260-1264 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.KeywordsDNA fragmentationspermatozoatestisclusterininfertilitymaleMetricsAuthor Information Adel Zalata Medical Biochemistry Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt More articles by this author Ayman Z. El-Samanoudy Medical Biochemistry Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt More articles by this author Dalia Shaalan Medical Biochemistry Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt More articles by this author Youssef El-Baiomy Dermatology and Andrology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt More articles by this author Mai Taymour Cairo University Hospitals, Cairo University, Cairo, Egypt More articles by this author Taymour Mostafa Andrology and Sexology Department, Faculty of Medicine, Cairo University, Cairo, Egypt More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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