Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012257631> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2012257631 endingPage "7788" @default.
- W2012257631 startingPage "7773" @default.
- W2012257631 abstract "Based on the structural analysis of fumitremorgin C (FTC), imidazoline and beta-carboline amino acid benzylester, 14 novel 2-substitutedtetracyclic derivatives of tetrahydrocarboline 4a-n were prepared. We demonstrated that the exposure of MES-SA/Dx5 cells to some of 4a-n resulted in significant reduction of resistance of the cells against doxorubicin. This reduced resistance was accompanied by lowering of IC(50) value to doxorubicin from 1.55+/-0.26 micromol/L to 0.33+/-0.05 micromol/L for 2-(2-butyl)-derivative 4c, to 1.03+/-0.22 micromol/L for 2-methyl-derivative 4d, to 0.46+/-0.04 micromol/L for 2-benzyl-derivative 4f, to 0.98+/-0.25 micromol/L for 2-indole-3-yl-methyl-derivative 4h, to 0.36+/-0.03 micromol/L for 2-benzyloxycarbonylmethyl-derivative 4i, to 0.77+/-0.08 micromol/L for 2-benzyloxycarbonylethyl-derivative 4j, and to 0.77+/-0.08 micromol/L for 2-benzyloxycarbonylamino-n-butyl-derivative 4l. Proliferation assays of 4a-n indicated 4c,f,i,j were able to inhibit the proliferation of doxorubicin resistant MES-SA/Dx5 cells. The SAR analysis revealed that the benzylester form and the tetracyclic structure of 4a-n were critical for both sensitizing doxorubicin and the cellular anti-proliferative effect." @default.
- W2012257631 created "2016-06-24" @default.
- W2012257631 creator A5014079161 @default.
- W2012257631 creator A5043633584 @default.
- W2012257631 creator A5070619167 @default.
- W2012257631 creator A5072942807 @default.
- W2012257631 creator A5077627175 @default.
- W2012257631 creator A5091859656 @default.
- W2012257631 date "2007-12-01" @default.
- W2012257631 modified "2023-10-04" @default.
- W2012257631 title "Dual-acting agents that possess reversing resistance and anticancer activities: Design, synthesis, MES-SA/Dx5 cell assay, and SAR of Benzyl 1,2,3,5,11,11a-hexahydro-3,3-dimethyl-1-oxo-6H-imidazo[3′,4′:1,2]pyridin[3,4-b]indol-2-substitutedacetates" @default.
- W2012257631 cites W1965976308 @default.
- W2012257631 cites W1968931590 @default.
- W2012257631 cites W2010587448 @default.
- W2012257631 cites W2022238255 @default.
- W2012257631 cites W2025629848 @default.
- W2012257631 cites W2045973642 @default.
- W2012257631 cites W2049832374 @default.
- W2012257631 cites W2050083092 @default.
- W2012257631 cites W2050287859 @default.
- W2012257631 cites W2051790091 @default.
- W2012257631 cites W2052008322 @default.
- W2012257631 cites W2101382252 @default.
- W2012257631 cites W2118234018 @default.
- W2012257631 cites W2173707883 @default.
- W2012257631 cites W4299127237 @default.
- W2012257631 doi "https://doi.org/10.1016/j.bmc.2007.08.061" @default.
- W2012257631 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17888666" @default.
- W2012257631 hasPublicationYear "2007" @default.
- W2012257631 type Work @default.
- W2012257631 sameAs 2012257631 @default.
- W2012257631 citedByCount "16" @default.
- W2012257631 countsByYear W20122576312012 @default.
- W2012257631 countsByYear W20122576312013 @default.
- W2012257631 countsByYear W20122576312014 @default.
- W2012257631 countsByYear W20122576312016 @default.
- W2012257631 countsByYear W20122576312017 @default.
- W2012257631 countsByYear W20122576312018 @default.
- W2012257631 countsByYear W20122576312019 @default.
- W2012257631 countsByYear W20122576312023 @default.
- W2012257631 crossrefType "journal-article" @default.
- W2012257631 hasAuthorship W2012257631A5014079161 @default.
- W2012257631 hasAuthorship W2012257631A5043633584 @default.
- W2012257631 hasAuthorship W2012257631A5070619167 @default.
- W2012257631 hasAuthorship W2012257631A5072942807 @default.
- W2012257631 hasAuthorship W2012257631A5077627175 @default.
- W2012257631 hasAuthorship W2012257631A5091859656 @default.
- W2012257631 hasConcept C106159729 @default.
- W2012257631 hasConcept C111771559 @default.
- W2012257631 hasConcept C162324750 @default.
- W2012257631 hasConcept C185592680 @default.
- W2012257631 hasConcept C2776694085 @default.
- W2012257631 hasConcept C2780783641 @default.
- W2012257631 hasConcept C2781303535 @default.
- W2012257631 hasConcept C54355233 @default.
- W2012257631 hasConcept C55493867 @default.
- W2012257631 hasConcept C62112901 @default.
- W2012257631 hasConcept C71240020 @default.
- W2012257631 hasConcept C81885089 @default.
- W2012257631 hasConcept C86803240 @default.
- W2012257631 hasConceptScore W2012257631C106159729 @default.
- W2012257631 hasConceptScore W2012257631C111771559 @default.
- W2012257631 hasConceptScore W2012257631C162324750 @default.
- W2012257631 hasConceptScore W2012257631C185592680 @default.
- W2012257631 hasConceptScore W2012257631C2776694085 @default.
- W2012257631 hasConceptScore W2012257631C2780783641 @default.
- W2012257631 hasConceptScore W2012257631C2781303535 @default.
- W2012257631 hasConceptScore W2012257631C54355233 @default.
- W2012257631 hasConceptScore W2012257631C55493867 @default.
- W2012257631 hasConceptScore W2012257631C62112901 @default.
- W2012257631 hasConceptScore W2012257631C71240020 @default.
- W2012257631 hasConceptScore W2012257631C81885089 @default.
- W2012257631 hasConceptScore W2012257631C86803240 @default.
- W2012257631 hasIssue "24" @default.
- W2012257631 hasLocation W20122576311 @default.
- W2012257631 hasLocation W20122576312 @default.
- W2012257631 hasOpenAccess W2012257631 @default.
- W2012257631 hasPrimaryLocation W20122576311 @default.
- W2012257631 hasRelatedWork W2349175154 @default.
- W2012257631 hasRelatedWork W2355034335 @default.
- W2012257631 hasRelatedWork W2358524133 @default.
- W2012257631 hasRelatedWork W2361020480 @default.
- W2012257631 hasRelatedWork W2362645172 @default.
- W2012257631 hasRelatedWork W2370855104 @default.
- W2012257631 hasRelatedWork W2372999700 @default.
- W2012257631 hasRelatedWork W2384155018 @default.
- W2012257631 hasRelatedWork W2588942881 @default.
- W2012257631 hasRelatedWork W3032871523 @default.
- W2012257631 hasVolume "15" @default.
- W2012257631 isParatext "false" @default.
- W2012257631 isRetracted "false" @default.
- W2012257631 magId "2012257631" @default.
- W2012257631 workType "article" @default.