Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012258189> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2012258189 endingPage "405" @default.
- W2012258189 startingPage "398" @default.
- W2012258189 abstract "Abstract. Platelet aggregability was studied in 18 healthy volunteers during mental stress (a colour word test; CWT) and low- and high-dose adrenaline infusions using an ex vivo technique (filtragometry) and conventional in vitro aggregometry. CWT and high-dose adrenaline (3–4 nmol 1-1 in plasma) shortened filtragometry readings, suggesting increased platelet aggregability in vivo. Low-dose adrenaline had no effect despite higher adrenaline levels in plasma (0.9 nmol I-1) than during CWT (0.4 nmol I-1). Platelet sensitivity to ADP in vitro was reduced following CWT and further reduced following adrenaline infusions. In vitro, adrenaline (50 nmol I-1) had little effect on platelet aggregation per se, but enhanced aggregability evoked by ADP (at ED50). Adrenaline potentiation of ADP-induced aggregation was enhanced after CWT, but was not related to filtragometry responsiveness to stress in vivo. Serum LDL-cholesterol levels were inversely correlated to filtragometry readings at rest, suggesting an adverse influence on platelet aggregability in vivo. HDL-cholesterol levels were inversely correlated to platelet sensitivity to ADP in vitro, suggesting a positive influence. Thus, sympathp-adre-nal activation enhances platelet aggregability in vivo (as assessed by ex vivo filtragometry), but adrenaline alone cannot explain the pro-aggregatory effect of mental stress. Serum lipoprotein alterations associated with increased risk for atherosclerosis seem to enhance platelet aggregability. The conventional in vitro technique may poorly reflect platelet aggregability in vivo.," @default.
- W2012258189 created "2016-06-24" @default.
- W2012258189 creator A5002513118 @default.
- W2012258189 creator A5009535255 @default.
- W2012258189 creator A5068373464 @default.
- W2012258189 creator A5087634388 @default.
- W2012258189 creator A5089563207 @default.
- W2012258189 date "2008-06-28" @default.
- W2012258189 modified "2023-10-03" @default.
- W2012258189 title "Platelet aggregability in humans: contrasting in vivo and in vitro findings during sympatho-adrenal activation and relationship to serum lipids" @default.
- W2012258189 cites W1966400382 @default.
- W2012258189 cites W1968671012 @default.
- W2012258189 cites W1975867565 @default.
- W2012258189 cites W2004239221 @default.
- W2012258189 cites W2021965061 @default.
- W2012258189 cites W2035724811 @default.
- W2012258189 cites W2038234821 @default.
- W2012258189 cites W2039448868 @default.
- W2012258189 cites W2043304436 @default.
- W2012258189 cites W2048794825 @default.
- W2012258189 cites W2072698989 @default.
- W2012258189 cites W2078328099 @default.
- W2012258189 cites W2080473110 @default.
- W2012258189 cites W2221112779 @default.
- W2012258189 cites W2400201077 @default.
- W2012258189 cites W2408373352 @default.
- W2012258189 cites W2413934378 @default.
- W2012258189 cites W2471711912 @default.
- W2012258189 doi "https://doi.org/10.1111/j.1365-2362.1990.tb01876.x" @default.
- W2012258189 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2121499" @default.
- W2012258189 hasPublicationYear "2008" @default.
- W2012258189 type Work @default.
- W2012258189 sameAs 2012258189 @default.
- W2012258189 citedByCount "33" @default.
- W2012258189 countsByYear W20122581892014 @default.
- W2012258189 crossrefType "journal-article" @default.
- W2012258189 hasAuthorship W2012258189A5002513118 @default.
- W2012258189 hasAuthorship W2012258189A5009535255 @default.
- W2012258189 hasAuthorship W2012258189A5068373464 @default.
- W2012258189 hasAuthorship W2012258189A5087634388 @default.
- W2012258189 hasAuthorship W2012258189A5089563207 @default.
- W2012258189 hasConcept C126322002 @default.
- W2012258189 hasConcept C134018914 @default.
- W2012258189 hasConcept C150903083 @default.
- W2012258189 hasConcept C185592680 @default.
- W2012258189 hasConcept C202751555 @default.
- W2012258189 hasConcept C207001950 @default.
- W2012258189 hasConcept C26291073 @default.
- W2012258189 hasConcept C2775859304 @default.
- W2012258189 hasConcept C2778163477 @default.
- W2012258189 hasConcept C3018697912 @default.
- W2012258189 hasConcept C55493867 @default.
- W2012258189 hasConcept C71924100 @default.
- W2012258189 hasConcept C86803240 @default.
- W2012258189 hasConcept C89560881 @default.
- W2012258189 hasConceptScore W2012258189C126322002 @default.
- W2012258189 hasConceptScore W2012258189C134018914 @default.
- W2012258189 hasConceptScore W2012258189C150903083 @default.
- W2012258189 hasConceptScore W2012258189C185592680 @default.
- W2012258189 hasConceptScore W2012258189C202751555 @default.
- W2012258189 hasConceptScore W2012258189C207001950 @default.
- W2012258189 hasConceptScore W2012258189C26291073 @default.
- W2012258189 hasConceptScore W2012258189C2775859304 @default.
- W2012258189 hasConceptScore W2012258189C2778163477 @default.
- W2012258189 hasConceptScore W2012258189C3018697912 @default.
- W2012258189 hasConceptScore W2012258189C55493867 @default.
- W2012258189 hasConceptScore W2012258189C71924100 @default.
- W2012258189 hasConceptScore W2012258189C86803240 @default.
- W2012258189 hasConceptScore W2012258189C89560881 @default.
- W2012258189 hasIssue "4" @default.
- W2012258189 hasLocation W20122581891 @default.
- W2012258189 hasLocation W20122581892 @default.
- W2012258189 hasOpenAccess W2012258189 @default.
- W2012258189 hasPrimaryLocation W20122581891 @default.
- W2012258189 hasRelatedWork W1144120039 @default.
- W2012258189 hasRelatedWork W1967434490 @default.
- W2012258189 hasRelatedWork W2000501579 @default.
- W2012258189 hasRelatedWork W2012258189 @default.
- W2012258189 hasRelatedWork W2038512896 @default.
- W2012258189 hasRelatedWork W2164696237 @default.
- W2012258189 hasRelatedWork W2359092312 @default.
- W2012258189 hasRelatedWork W2395680210 @default.
- W2012258189 hasRelatedWork W2460584456 @default.
- W2012258189 hasRelatedWork W2748952813 @default.
- W2012258189 hasVolume "20" @default.
- W2012258189 isParatext "false" @default.
- W2012258189 isRetracted "false" @default.
- W2012258189 magId "2012258189" @default.
- W2012258189 workType "article" @default.